PAF Cancer Research Results

PAF, platelet-activating factor: Click to Expand ⟱
Source:
Type:

Platelet-activating factor (PAF) is a potent bioactive phospholipid mediator involved in inflammation, platelet activation, vascular permeability, leukocyte recruitment, bronchoconstriction and immune signalling. PAF acts primarily through the platelet-activating factor receptor (PTAFR / PAFR), a G-protein-coupled receptor. Excessive PAF signalling can contribute to inflammatory and vascular injury and has also been implicated in tumour-cell proliferation, migration, angiogenesis and metastasis in some cancers. In the nervous system, excessive PAF signalling can promote neuroinflammation, oxidative stress and excitotoxic neuronal injury, although physiological PAF also participates in synaptic signalling. Therefore, pathological PAF activity is generally considered up in inflammatory disease contexts, while the desired modulation is typically down or PAF-receptor antagonism. Ginkgolides, particularly ginkgolide B, are well-characterized antagonists of the PAF receptor and contribute to the pharmacological activity of standardized Ginkgo biloba extracts such as EGb 761.



Scientific Papers found: Click to Expand⟱
7229- EGb 761,    Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia
- Review, AD, NA
*toxicity↓, *Dose↝, *ROS↓, *PAF↓, *memory↑, *BloodF↑, *antiOx↑, *Inflam↓, *Tinn↓,
7228- EGb 761,    Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders
- Review, AD, NA
*Dose↝, *PAF↑, *AntiAg↑, *BloodF↑, *Inflam↓, *neuroP↑, *Stroke↓, *Dose↝, *Sepsis↓, *memory↑,
7268- GGB,    Ginkgolide B inhibits the neurotoxicity of prions or amyloid-beta1-42
- in-vitro, AD, NA
*PGE2↓, *Casp3↓, *neuroP↑, *PAF↑,
7271- GGB,    Ginkgolide B Regulates CDDP Chemoresistance in Oral Cancer via the Platelet-Activating Factor Receptor Pathway
- in-vitro, Oral, NA
PAF↓, ChemoSen↑, Apoptosis↑,
7273- GGB,    Platelet-activating factor induces the stemness of ovarian cancer cells via the PAF/PAFR signaling pathway
- vitro+vivo, Ovarian, NA
PAF↓, CSCs↓,
7217- GGB,    Role of Ginkgolides in the Inflammatory Immune Response of Neurological Diseases: A Review of Current Literatures
- Review, AD, NA
*eff↑, *AntiAg↑, *Apoptosis↓, *antiOx↑, *Inflam↓, *MAPK↓, *NF-kB↓, *PAF↓, *TLR1↓, *MyD88↓, *BDNF↑, *ROS↓, *PARP↓, *Cyt‑c↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PAF↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

PAF↓, 2,   PAF↑, 2,   Stroke↓, 1,   Tinn↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ROS↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Cyt‑c↓, 1,   MAPK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 3,   MyD88↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TLR1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 3,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 2,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 2,   neuroP↑, 2,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 25

Scientific Paper Hit Count for: PAF, platelet-activating factor
4 Ginkgolide B
2 Ginkgo biloba-EGb 761
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1611  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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