PAI-1/SERPINE1 Cancer Research Results

PAI-1/SERPINE1, plasminogen activator inhibitor-1: Click to Expand ⟱

Source:

Type:

PAI-1 (plasminogen activator inhibitor-1; SERPINE1) is a secreted serine-protease inhibitor that primarily inhibits tissue-type and urokinase-type plasminogen activators (tPA/PLAT and uPA/PLAU), thereby regulating plasmin generation, fibrinolysis and extracellular-matrix remodeling. In many cancers, PAI-1 is overexpressed by tumour cells and stromal cells and can promote tumour-cell survival, migration, invasion, angiogenesis, epithelial–mesenchymal transition, metastasis and resistance to therapy through both protease-dependent and signalling functions involving interactions with vitronectin, integrins and LRP1. High tumour or circulating PAI-1 is associated with poor prognosis in several malignancies, particularly breast cancer. The typical cancer-associated direction is therefore generally up, while the desired anticancer modulation is commonly down or functional inhibition. PAI-1 is also strongly associated with cellular senescence and is frequently used as a component of the senescence-associated secretory phenotype (SASP), although elevated PAI-1 alone is not sufficient to establish cellular senescence. PAI-1 is kept separate from PAI-2/SERPINB2 and from its upstream plasminogen activators uPA and tPA.

In cancer, PAI-1 is commonly upregulated and is associated with invasion, angiogenesis, metastasis, treatment resistance, and poor prognosis, although its biology is context-dependent.

Scientific Papers found: Click to Expand⟱

7224-

GAs,

Ginkgolic acids inhibit migration in breast cancer cells by inhibition of NEMO sumoylation and NF-κB activity

in-vitro,

BC,

MCF7

in-vitro,

BC,

MDA-MB-231

Wound Healing↓, uPA↓, PAI-1/SERPINE1↓, CXCR4↓, MMP9↓, TumCMig↓, NF-kB↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Migration(tgid=13) ⓘ

MMP9↓, 1, PAI-1/SERPINE1↓, 1, TumCMig↓, 1, uPA↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CXCR4↓, 1, NF-kB↓, 1,

Functional Outcomes(tgid=23) ⓘ

Wound Healing↓, 1,
Total Targets: 7

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: PAI-1/SERPINE1, plasminogen activator inhibitor-1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells