CES2 Cancer Research Results

CES2, Carboxylesterase 2: Click to Expand ⟱
Source:
Type:

CES2 - Carboxylesterase 2

Abbreviation: CES2

Type: Serine hydrolase / carboxylesterase

Function: Hydrolyzes ester- and amide-containing compounds and participates in lipid and xenobiotic metabolism. CES2 is important in cancer pharmacology because it converts irinotecan to the active metabolite SN-38 and contributes to activation/metabolism of other ester-containing anticancer drugs.

Cancer: ↕ Context-dependent. High CES2 can increase sensitivity to irinotecan and improve response to irinotecan-containing therapy, but tumor-intrinsic CES2 activity can also support metabolic pathways and tumor growth in some cancers such as pancreatic ductal adenocarcinoma. Direction should therefore be interpreted according to cancer type and treatment context.
Scientific Papers found: Click to Expand⟱
7255- Gink,    Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2
- Study, NA, NA
*CES2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CES2↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: CES2, Carboxylesterase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1614  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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