GALNT10 Cancer Research Results

GALNT10, Glycosyltransferase / O-GalNAc transferase: Click to Expand ⟱
Source:
Type:

GALNT10 - Polypeptide N-Acetylgalactosaminyltransferase 10

Abbreviation: GALNT10

Type: Glycosyltransferase / O-GalNAc transferase

Function: Initiates mucin-type O-linked glycosylation by transferring N-acetylgalactosamine (GalNAc) to serine or threonine residues of protein substrates. GALNT10 can alter protein secretion, signaling, cell adhesion, epithelial-mesenchymal transition, and tumor-microenvironment interactions through substrate-specific O-glycosylation.

Cancer: ↑ Increased GALNT10 activity/expression can promote tumor progression and metastasis. In ovarian cancer, GALNT10 promotes EMT and metastatic vascular remodeling through O-glycosylation of IGFBP7, enhancing its secretion and subsequent CD93-mediated endothelial signaling.
Scientific Papers found: Click to Expand⟱
7266- Gink,    Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF7
Casp3↑, BAX↑, Cyt‑c↑, Bcl-2↓, TumCP↓, TumCMig↓, Apoptosis↑, miR-122-5p↑, GALNT10↓, TumCG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

GALNT10↓, 1,   miR-122-5p↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GALNT10, Glycosyltransferase / O-GalNAc transferase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1617  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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