APE1/APEX1 Cancer Research Results

APE1/APEX1, Apurinic/Apyrimidinic Endonuclease 1 / Redox Effector Factor 1: Click to Expand ⟱
Source:
Type:

APE1 - Apurinic/Apyrimidinic Endonuclease 1 / Redox Effector Factor 1

Abbreviation: APE1, APEX1, Ref-1

Type: DNA repair enzyme / redox regulatory protein

Function: Multifunctional protein that performs apurinic/apyrimidinic endonuclease activity in the base-excision repair (BER) pathway and also regulates the redox state and DNA-binding activity of transcription factors including NF-κB, HIF-1α, STAT3, and AP-1. APE1 supports DNA repair, oxidative-stress resistance, cell survival, angiogenesis, and transcriptional signaling.

Cancer: ↑ Frequently increased or activated in cancer. Elevated APE1/Ref-1 promotes DNA-damage repair, tumor-cell survival, proliferation, angiogenesis, and resistance to chemotherapy and radiotherapy. Inhibition of APE1 DNA-repair or redox activity can increase tumor-cell sensitivity to DNA-damaging therapies and suppress oncogenic transcription-factor signaling.
Scientific Papers found: Click to Expand⟱
7311- Gos,    Systematic Review of Gossypol/AT-101 in Cancer Clinical Trials
- Review, CLL, NA
Dose↝, toxicity↓, PFS↓, OS↑, eff↑, BioAv↑, Bcl-2↓, ROS↑, MOMP↑, Dose↑, Casp3↑, Casp9↑, MMP↑, VEGF↓, APE1/APEX1↓, ChemoSen↑, RadioS↑, toxicity↑, AST↑, ALAT↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APE1/APEX1↓, 1,   PFS↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↑, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   MOMP↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   RadioS↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↑, 1,   AST↑, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   toxicity↓, 1,   toxicity↑, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: APE1/APEX1, Apurinic/Apyrimidinic Endonuclease 1 / Redox Effector Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1620  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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