Ku70/XRCC6 Cancer Research Results

Ku70/XRCC6, X-Ray Repair Cross-Complementing Protein 6: Click to Expand ⟱
Source:
Type:

Ku70 - X-Ray Repair Cross-Complementing Protein 6

Abbreviation: Ku70, XRCC6

Type: DNA double-strand break repair protein / NHEJ component

Function: Ku70 forms a heterodimer with Ku80 (XRCC5) that rapidly binds DNA double-strand break ends and initiates classical non-homologous end joining (NHEJ). The Ku70/Ku80 complex protects broken DNA ends and recruits DNA-PKcs and additional repair proteins required for DNA-end processing and ligation. Ku70 also participates in telomere maintenance, apoptosis regulation, and cellular DNA-damage responses.

Cancer: ↑ Increased Ku70/XRCC6 expression or NHEJ activity can enhance tumor-cell survival following DNA damage and contribute to resistance to radiotherapy and DNA-damaging chemotherapy. High XRCC6 expression has been associated with tumor progression and poorer prognosis in several cancers. However, loss of Ku70-mediated DNA repair can also increase genomic instability and cancer susceptibility, so its role differs between tumor initiation and treatment of established cancers.
Scientific Papers found: Click to Expand⟱
8342- Lut,  Cisplatin,    Lutein Influences Cisplatin Sensitivity Through Differential Regulation of DNA Damage Response Genes in Breast Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
tumCV↓, DNAdam↑, selectivity↑, ROS↑, Casp3↑, BRCA1↓, Ku70/XRCC6↓, XRCC1↓, ChemoSen↑, NA↓,
7378- RS,    Reserpine inhibits DNA repair, cell proliferation, invasion and induces apoptosis in oral carcinogenesis via modulation of TGF-β signaling
*antiOx↑, *AntiBio↑, TGF-β↓, p‑SMAD3↓, p‑SMAD2↓, p‑SMAD4↓, SMAD3↓, Snail↓, ERCC1↓, ERCC4/XPF↓, Ku70/XRCC6↓, PCNA↓, cycD1/CCND1↓, Hif1a↓, IL6↓, Mcl-1↓, BAX↑, Cyt‑c↑, APAF1↑, Casp9↑, Casp3↑, PARP↑, DNArepair↓, TumCP↓, TumCI↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ERCC4/XPF↓, 1,   Ku70/XRCC6↓, 2,   NA↓, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ERCC1↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   BAX↑, 1,   Casp3↑, 2,   Casp9↑, 1,   Cyt‑c↑, 1,   Mcl-1↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   DNAdam↑, 1,   DNArepair↓, 1,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Migration(tgid=13) ⓘ

p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   p‑SMAD4↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   IL6↓, 1,  
Total Targets: 33

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Ku70/XRCC6, X-Ray Repair Cross-Complementing Protein 6
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1632  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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