OTUB2 Cancer Research Results

OTUB2, OTU Deubiquitinase: Click to Expand ⟱
Source:
Type:

OTUB2 - OTU Deubiquitinase, Ubiquitin Aldehyde Binding 2

Abbreviation: OTUB2

Type: Deubiquitinating enzyme / OTU-family cysteine protease

Function: OTUB2 removes ubiquitin modifications from selected protein substrates and thereby regulates protein stability, signaling, DNA-damage responses, metabolism, and cell proliferation. OTUB2 can modulate K48- and K63-linked ubiquitination and participate in regulation of DNA double-strand break repair.

Cancer: ↑ Frequently increased or oncogenic in multiple cancers. OTUB2 can stabilize oncogenic substrates including PKM2 and KRT80, promoting glycolysis, PI3K/AKT signaling, proliferation, migration, invasion, and metastasis. OTUB2 inhibition or knockdown suppresses tumor-cell growth and progression in several experimental cancer models.
Scientific Papers found: Click to Expand⟱
7458- HNK,    Honokiol induces ferroptosis in ovarian cancer cells through the regulation of YAP by OTUB2
- in-vitro, Ovarian, OVCAR-3
TumCP↓, TumCI↓, Ferroptosis↑, YAP/TEAD↓, OTUB2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

OTUB2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,   YAP/TEAD↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: OTUB2, OTU Deubiquitinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1643  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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