ODC1 Cancer Research Results

ODC1, Ornithine Decarboxylase 1: Click to Expand ⟱
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ODC1 - Ornithine Decarboxylase 1

Abbreviation: ODC1, ODC

Type: Polyamine biosynthesis enzyme / pyridoxal phosphate-dependent decarboxylase

Function: Catalyzes the decarboxylation of ornithine to putrescine, the rate-limiting and committed step in polyamine biosynthesis. ODC1 regulates production of putrescine, spermidine, and spermine and thereby influences cell proliferation, growth, differentiation, apoptosis, metabolic signaling, and cellular stress responses.

Cancer: ↑ Frequently increased or overactivated in cancer and is a major downstream target of MYC signaling. Elevated ODC1 increases polyamine synthesis and can promote proliferation, tumor growth, angiogenesis, migration, invasion, and survival. ODC1 inhibition, including with DFMO/eflornithine, suppresses proliferation and tumor growth in multiple experimental cancer models.

Alzheimer's Disease: ↑ Increased astrocytic ODC1 activity is associated with Alzheimer's disease pathology and abnormal astrocytic putrescine/GABA metabolism. Experimental inhibition of astrocytic ODC1 reduces aberrant GABA production, improves memory deficits, and can markedly reduce hippocampal Aβ plaque burden in APP/PS1 models.
Scientific Papers found: Click to Expand⟱
Showing Research Papers: 0 to 0 of 0

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ODC1, Ornithine Decarboxylase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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