E2F4 Cancer Research Results

E2F4, E2F Transcription Factor 4: Click to Expand ⟱
Source:
Type:

E2F4 - E2F Transcription Factor 4

Type: Transcription factor / cell-cycle regulator

Function: E2F4 is a member of the E2F transcription-factor family that regulates genes involved in cell-cycle progression, DNA replication, differentiation, and quiescence. E2F4 frequently forms repressive complexes with RB-family proteins including p107/RBL1 and p130/RBL2 and is an important component of the DREAM complex that suppresses cell-cycle gene expression in quiescent cells.

Cancer: ↓ Typically reduced or functionally impaired as a cell-cycle repressor. Loss of E2F4-mediated transcriptional repression can promote inappropriate expression of S-phase and proliferation-associated genes. However, E2F4 can show context-dependent oncogenic activity in some tumors.

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Scientific Papers found: Click to Expand⟱
7507- FA,    Assessment of the anticancer mechanism of ferulic acid via cell cycle and apoptotic pathways in human prostate cancer cell lines
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3
Dose↝, ATR↑, ATM↑, P21↑, p27/CDKN1B↑, E2F4↑, RB1↑, TP53↑, cycD1/CCND1↓, CDK2↓, CDK4↓, CDK6↓, TumCP↓, Casp1↑, Casp2↑, Casp8↑, Fas↑, TRADD↑, Bcl-2↓, XIAP↓, TumCCA↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

E2F4↑, 1,   TRADD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   Casp1↑, 1,   Casp2↑, 1,   Casp8↑, 1,   Fas↑, 1,   p27/CDKN1B↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   ATR↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   P21↑, 1,   RB1↑, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

TP53↑, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: E2F4, E2F Transcription Factor 4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1653  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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