URGCP/URG4 Cancer Research Results

URGCP/URG4, Upregulator of Cell Proliferation: Click to Expand ⟱
Source:
Type:

URGCP - Upregulator of Cell Proliferation

Abbreviation: URGCP, URG4

Type: Oncogenic cell-proliferation regulatory protein

Function: URGCP/URG4 is a cell-proliferation regulator originally identified as a gene induced by hepatitis B virus X protein (HBx). It promotes cell-cycle progression, proliferation, survival, and tumorigenic signaling and can regulate pathways involving AKT, FOXO3a, GSK3β/β-catenin, cyclin D1, p21/CDKN1A, and p27/CDKN1B.

Cancer: ↑ Frequently increased and oncogenic. Elevated URGCP/URG4 promotes G1/S cell-cycle progression, proliferation, survival, migration, tumor growth, and metastatic behavior. In hepatocellular carcinoma, increased URGCP is associated with advanced disease and poor survival and can increase AKT and cyclin D1 while suppressing FOXO3a, p21, and p27 activity.
Scientific Papers found: Click to Expand⟱
7513- FA,    Anti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCP
- in-vitro, Thyroid, NA
cycD1/CCND1↓, URGCP/URG4↓, CDK4↓, CDK6↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, BAX↑, Casp3↑, Casp9↑, TIMP1↑, TumCI↓, TumCMig↓, TumCCA↑, Apoptosis↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

URGCP/URG4↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   NOXA↑, 1,   PUMA↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: URGCP/URG4, Upregulator of Cell Proliferation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1655  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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