NOX2 Cancer Research Results

NOX2, NADPH Oxidase 2: Click to Expand ⟱
Source:
Type:

NOX2 - NADPH Oxidase 2 / Cytochrome b-245 Beta Chain

Abbreviation: NOX2, CYBB, gp91phox

Type: NADPH oxidase / reactive oxygen species-generating enzyme

Function: NOX2 is the catalytic membrane subunit of the phagocytic NADPH oxidase complex and generates superoxide during immune and inflammatory responses. It is highly expressed in neutrophils, macrophages, and microglia and regulates antimicrobial defense, redox signaling, inflammation, vascular function, and cellular responses to injury.

Cancer: ↑ Increased NOX2 activity within tumor cells and particularly tumor-associated immune cells can promote ROS-dependent survival signaling, inflammation, immune suppression, angiogenesis, invasion, and tumor progression. NOX2-derived ROS from tumor-associated macrophages and other myeloid cells can suppress antitumor lymphocyte function.

Alzheimer's Disease: ↑ Increased and overactivated NOX2 is strongly implicated in Alzheimer's disease. Aβ stimulates microglial NOX2 activity, increasing ROS production, oxidative stress, neuroinflammation, cerebrovascular dysfunction, and neuronal injury. NOX2 inhibition or genetic deletion reduces oxidative and cognitive abnormalities in experimental Alzheimer's disease models.
Scientific Papers found: Click to Expand⟱
7703- ,    Inositol hexaphosphate-induced cellular response in myeloid leukemia cells is mediated by nicotinamide adenine dinucleotide phosphate oxidase activation
- in-vitro, AML, PLB-985
TumCG↓, TumCD↑, Diff↑, NOX2↑, ROS↑,
7563- HYP,    Hyperoside alleviates macrophages and microglia-mediated neuroinflammation and oxidative stress through activating PI3K/AKT and Nrf2/HO-1 signaling pathway post spinal cord injury
- vitro+vivo, Nor, NA
*Inflam↓, *antiOx↑, *Dose↝, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *NOX4↓, *NOX2↓, *NOX1↓, *PI3K↑, *Akt↑, *NRF2↑, *HO-1↑, *neuroP↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NOX2↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

TumCD↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   TumCG↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NOX1↓, 1,   NOX2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   NOX4↓, 1,   NRF2↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   iNOS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 17

Scientific Paper Hit Count for: NOX2, NADPH Oxidase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1660  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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