UBE2L3/UBCH7 Cancer Research Results

UBE2L3/UBCH7, Ubiquitin-Conjugating Enzyme E2 L3: Click to Expand ⟱

Source:

Type:

UBE2L3 - Ubiquitin-Conjugating Enzyme E2 L3

Abbreviation: UBE2L3, UBCH7, UBCM4

Type: E2 ubiquitin-conjugating enzyme

Function: UBE2L3 transfers activated ubiquitin from E1 enzymes to substrates in cooperation with specific E3 ubiquitin ligases. It regulates protein stability, cell-cycle progression, NF-κB signaling, DNA-damage responses, proliferation, and cellular homeostasis through substrate-specific ubiquitination.

Cancer: ↑ Frequently increased and oncogenic in several cancer contexts. Elevated UBE2L3 can promote proliferation, cell-cycle progression, tumor growth, and survival through ubiquitination-dependent regulation of proteins including p27/CDKN1B and components of oncogenic signaling pathways. High UBE2L3 expression has been associated with advanced disease and poorer outcomes in non-small-cell lung cancer. Its effects can vary depending on the associated E3 ligase and substrate.

Scientific Papers found: Click to Expand⟱

7587-

I3C,

Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest

in-vitro,

Cerv,

HeLa

500 µM

AhR↑, UBE2L3/UBCH7↑, Dose↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

UBE2L3/UBCH7↑, 1,

Cell Death(tgid=5) ⓘ

AhR↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: UBE2L3/UBCH7, Ubiquitin-Conjugating Enzyme E2 L3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells