TF-Ag Cancer Research Results

TF-Ag, Thomsen-Friedenreich Antigen / Galβ1-3GalNAc: Click to Expand ⟱
Source:
Type:

TF Antigen - Thomsen-Friedenreich Antigen / Galβ1-3GalNAc

Abbreviation: TF antigen, TF-Ag, T antigen, CD176

Type: Tumor-associated carbohydrate antigen / truncated O-glycan

Function: The Thomsen-Friedenreich antigen consists of galactose linked β1-3 to N-acetyl-D-galactosamine (Galβ1-3GalNAc), typically attached to serine or threonine residues of glycoproteins. In normal tissues this carbohydrate structure is usually further glycosylated or masked, whereas abnormal O-glycosylation in malignant cells can expose the TF antigen on the cell surface.

Cancer: ↑ Frequently increased or exposed in carcinomas. TF antigen expression is associated with abnormal tumor glycosylation, cell adhesion, galectin-3 interactions, invasion, endothelial attachment, and metastatic dissemination.
Scientific Papers found: Click to Expand⟱
7641- Ins,    Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
- Review, CRC, NA
AntiCan↑, p‑Akt↓, TF-Ag↓, *PI3K↓, *AP-1↓, *DNArepair↑, *BioAv↑, *BBB↑, *other↑, *PGE2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TF-Ag↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PGE2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: TF-Ag, Thomsen-Friedenreich Antigen / Galβ1-3GalNAc
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1676  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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