ABCG1 Cancer Research Results

ABCG1, ATP-Binding Cassette Subfamily G Member 1: Click to Expand ⟱
Source:
Type:

ABCG1 - ATP-Binding Cassette Subfamily G Member 1

Type: ATP-binding cassette lipid transporter / cholesterol efflux transporter

Function: ABCG1 is an ATP-dependent membrane transporter that regulates intracellular cholesterol and phospholipid homeostasis, particularly by promoting cholesterol efflux to mature HDL particles. ABCG1 influences membrane lipid composition, lipid-raft signaling, macrophage function, cellular metabolism, and inflammatory responses.

Cancer: ↕ Context-dependent, with a predominantly tumor-promoting pattern in many cancers. Elevated ABCG1 can support cancer-cell survival, stem-like properties, proliferation, chemoresistance, Akt-associated signaling, and tumor-promoting macrophage polarization. However, in some cancer models increased ABCG1-mediated cholesterol efflux depletes cellular cholesterol and suppresses proliferation or promotes apoptosis.

Alzheimer's Disease: ↕ Context-dependent. ABCG1 regulates cholesterol efflux and membrane cholesterol distribution and can influence α-, β-, and γ-secretase activity and Aβ production. Experimental studies report both increased and decreased Aβ following ABCG1 modulation, so a consistent disease-associated direction has not been established.
Scientific Papers found: Click to Expand⟱
7701- IP6,    Inositol hexaphosphate sensitizes hepatocellular carcinoma to oxaliplatin relating inhibition of CCN2-LRP6-β-catenin-ABCG1 signaling pathway
- vitro+vivo, HCC, Hep3B - NA, NA, MHCC-97H
AntiCan↑, ChemoSen↑, LRP6↓, Wnt↓, β-catenin/ZEB1↓, CCN2/CTGF↓, ABCG1↓, TumCP↓, TumCMig↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCG1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

LRP6↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

CCN2/CTGF↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ABCG1, ATP-Binding Cassette Subfamily G Member 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1684  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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