FABP5/E-FABP Cancer Research Results

FABP5/E-FABP, Fatty Acid-Binding Protein 5 / Epidermal Fatty Acid-Binding Protein: Click to Expand ⟱

Source:

Type:

FABP5 - Fatty Acid-Binding Protein 5 / Epidermal Fatty Acid-Binding Protein

Abbreviation: FABP5, E-FABP

Type: Intracellular lipid-binding protein / fatty-acid chaperone

Function: FABP5 binds long-chain fatty acids and other hydrophobic ligands and transports them between cellular compartments. It regulates fatty-acid uptake and trafficking, lipid metabolism, transcriptional signaling, cellular proliferation, differentiation, inflammatory responses, and metabolic adaptation. FABP5 can deliver lipid ligands to nuclear receptors including PPARβ/δ and thereby influence gene expression involved in survival and lipid metabolism.

Cancer: ↑ Frequently overexpressed in cancer and generally associated with a tumor-promoting phenotype. Elevated FABP5 can support fatty-acid utilization, metabolic reprogramming, proliferation, survival, migration, invasion, metastasis, cancer stem-like properties, immune-microenvironment changes, and treatment resistance. High tumor FABP5 expression is associated with poor prognosis in multiple cancers, although tumor-suppressive effects have been reported in selected cancer types.

Scientific Papers found: Click to Expand⟱

7757-

ISL,

Isoliquiritigenin Suppresses Oral Squamous Cell Carcinoma Progression by Targeting FABP5-Mediated Lipid Metabolism: Association with the circPOLB/miR-548ae-3p/C-MYC Axis

in-vitro,

Oral,

FABP5/E-FABP↓, FAM↓, TumCI↓, lipidLev↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

FABP5/E-FABP↓, 1, FAM↓, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

lipidLev↓, 1,

Migration(tgid=13) ⓘ

TumCI↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: FABP5/E-FABP, Fatty Acid-Binding Protein 5 / Epidermal Fatty Acid-Binding Protein

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells