circNAV3 Cancer Research Results

circNAV3, Circular RNA Derived from NAV3: Click to Expand ⟱
Source:
Type:

circNAV3 - Circular RNA Derived from NAV3

Specific ID: hsa_circ_0008509

Type: Circular non-coding RNA / post-transcriptional regulator

Function: circNAV3 is a circular RNA generated from the NAV3 genomic locus. In triple-negative breast cancer, circNAV3 can function as a competing endogenous RNA by sequestering miR-4262, thereby increasing ST6GALNAC5 expression. Increased ST6GALNAC5 promotes sialylation and activation of EGFR signaling, contributing to tumor growth, angiogenesis, and metastatic behavior.

Cancer: ↑ Increased circNAV3 has been identified in triple-negative breast cancer brain metastases and is associated with unfavorable clinical outcome. Experimental overexpression promotes tumorigenesis, angiogenesis, and brain metastasis through the circNAV3/miR-4262/ST6GALNAC5/EGFR signaling axis. Suppression of circNAV3 inhibits these metastatic effects.
Scientific Papers found: Click to Expand⟱
7762- ISL,    Isoliquiritigenin reduces brain metastasis by circNAV3-ST6GALNAC5-EGFR axis in triple-negative breast cancer
- in-vivo, BC, NA
TumMeta↓, circNAV3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

circNAV3↓, 1,  

Migration(tgid=13) ⓘ

TumMeta↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: circNAV3, Circular RNA Derived from NAV3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1694  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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