NGB Cancer Research Results

NGB, Neuroglobin: Click to Expand ⟱
Source:
Type:

NGB - Neuroglobin

Type: Heme-containing globin / oxygen- and redox-responsive cytoprotective protein

Function: Neuroglobin is a predominantly neuronal heme protein involved in cellular responses to hypoxia, ischemia, oxidative stress, and mitochondrial dysfunction. NGB can modulate reactive oxygen and nitrogen species, mitochondrial signaling, calcium homeostasis, energy metabolism, and apoptotic pathways and generally promotes neuronal survival under metabolic or oxidative stress.

Cancer: ↑ Frequently increased in several cancers and may function as a cytoprotective survival factor. Elevated NGB can help tumor cells tolerate hypoxia, oxidative stress, mitochondrial dysfunction, and apoptotic signaling, thereby supporting cancer-cell survival and potentially treatment resistance.

Alzheimer's Disease: ↓ / protective when increased. Reduced or inadequate NGB-mediated neuroprotection may contribute to vulnerability to oxidative and mitochondrial injury, whereas increased NGB expression protects against amyloid-β toxicity, mitochondrial dysfunction, oxidative stress, and neuronal apoptosis in experimental models. Therapeutic NGB upregulation is therefore generally considered favorable.
Scientific Papers found: Click to Expand⟱
7813- ISQ,    Isoquercitrin Played a Neuroprotective Role in Rats After Cerebral Ischemia/Reperfusion Through Up-Regulating Neuroglobin and Anti-Oxidative Stress
- in-vivo, Stroke, NA
*Apoptosis↓, *ROS↓, *SOD↑, *GSH↑, *Catalase↑, *NRF2↑, *HO-1↑, *MDA↓, *NGB↑, *neuroP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

NGB↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: NGB, Neuroglobin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1700  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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