compV Cancer Research Results

compV, Mitochondrial Complex V: Click to Expand ⟱
Source:
Type:

Mitochondrial Complex V - ATP Synthase / F1Fo ATP Synthase

Abbreviation: Complex V, ATP synthase, F1Fo-ATP synthase

Type: Mitochondrial oxidative phosphorylation complex / ATP-producing enzyme complex

Function: Mitochondrial Complex V is the ATP synthase of the inner mitochondrial membrane. It uses the proton-motive force generated by respiratory-chain Complexes I, III, and IV to phosphorylate ADP to ATP. Complex V consists of a membrane-embedded Fo proton-translocation domain and a matrix-facing F1 catalytic domain and is composed of multiple nuclear- and mitochondrial-encoded subunits.

Cancer: ↕ Context-dependent. Complex V activity and expression are altered during cancer metabolic reprogramming. Tumors dependent on oxidative phosphorylation may maintain or increase ATP synthase activity to support ATP production, growth, survival, and treatment resistance, whereas glycolytic tumors may show reduced oxidative-phosphorylation activity. Individual ATP synthase subunits can display tumor-specific increases or decreases.

Alzheimer's Disease: ↓ Impaired mitochondrial Complex V activity and ATP production are associated with Alzheimer's disease. Altered ATP synthase subunit expression, oxidative damage, mitochondrial membrane dysfunction, and reduced oxidative phosphorylation contribute to cellular energy failure, synaptic dysfunction, and neuronal vulnerability.
Scientific Papers found: Click to Expand⟱
8703- BMF,    Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism
- in-vitro, Var, NA
HMGCR↓, CSCs↓, ALDH↓, STAT3↓, NOTCH↓, Wnt↓, β-catenin/ZEB1↓, OXPHOS↓, FAO↓, selectivity↑, Ingr↝, HMG-CoA↓, Rho↓, p27/CDKN1B↑, mitResp↓, compI↓, compII↓, compIV↓, compV↓, OCR↓, ATP↓,
7817- ISQ,  MOR,    Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis
- in-vitro, AD, NA
*neuroP?, *compI↑, *compIII↑, *compV↑, *p‑ERK↑,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8728- M-Blu,    Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
- Review, AD, NA
*Dose↝, *antiOx↑, *mitResp↑, *neuroP↑, *memory↑, *CellMemb↑, *BBB↑, *other↝, *compV↑, *OCR↑, *ROS↓, *Sepsis↓, *NO↓, *RNS↓, *memory↑, *tau↓, *CX43/GJA1↑, *THBD↑, *CARTPT↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx4↓, 1,   GSH↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   compI↓, 2,   compII↓, 1,   compIII↓, 1,   compIV↓, 1,   compV↓, 2,   ETC↓, 1,   mitResp↓, 1,   OCR↓, 1,   OXPHOS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   FAO↓, 1,   HK1↓, 1,   HMG-CoA↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   Ferroptosis↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   p‑ERK↓, 1,   p‑MAP2K1/MEK1↓, 1,   p‑MAPK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

FOXO1↓, 1,   miR-107↑, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↑, 1,   miR-384↑, 1,   miR-422a↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↓, 1,   ERCC3↑, 1,   P53↑, 1,   XRCC1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

p‑CHK1↑, 1,   CycB/CCNB1↓, 1,   Ki-67↓, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CSCs↓, 1,   HMGCR↓, 1,   Ki-67↓, 1,   NOTCH↓, 2,   TumCP?, 1,   TumCP↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   MMP16↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Rho↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   NF-kB↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   selectivity↑, 1,   Synergy↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 79

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   RNS↓, 1,   ROS↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↑, 1,   compIII↑, 1,   compV↑, 2,   mitResp↑, 1,   OCR↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑ERK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   CX43/GJA1↑, 1,   THBD↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

CARTPT↑, 1,  

Protein Aggregation(tgid=19) ⓘ

tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 2,   neuroP?, 1,   neuroP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 22

Scientific Paper Hit Count for: compV, Mitochondrial Complex V
1 Brutieridin–Melitidin Mixture
1 isoquercitrin
1 Morin
1 Luteolin
1 Methylene blue
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1701  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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