Aβ42 Cancer Research Results

Aβ42, Amyloid Beta 1-42: Click to Expand ⟱
Source:
Type:

Aβ42 - Amyloid Beta 1-42

Type: Amyloid peptide / Alzheimer's disease pathological protein / biomarker

Function: Aβ42 is a 42-amino-acid amyloid-beta peptide generated from amyloid precursor protein (APP) through sequential cleavage by β-secretase and γ-secretase. Compared with shorter Aβ species such as Aβ40, Aβ42 is more hydrophobic and aggregation-prone and readily forms oligomers, fibrils, and amyloid plaques.

Alzheimer's Disease: ↑ in aggregated brain deposits / ↓ in soluble CSF. Aβ42 is a major component of cerebral amyloid plaques and its aggregation is a defining feature of Alzheimer's disease pathology. Increased accumulation of oligomeric and fibrillar Aβ42 is associated with synaptic dysfunction, neuroinflammation, oxidative stress, and neuronal injury. In contrast, soluble CSF Aβ42 typically decreases as cerebral amyloid deposition increases, and a reduced CSF or plasma Aβ42/Aβ40 ratio is used as a biomarker of amyloid pathology.
Scientific Papers found: Click to Expand⟱
9067- L-THE,    l-Theanine Ameliorates d-Galactose-Induced Brain Damage in Rats via Inhibiting AGE Formation and Regulating Sirtuin1 and BDNF Signaling Pathways
- in-vivo, AD, NA
*AGEs↓, *Aβ42↓, *Ach↑, *AChE↓, *NF-kB↓, *SIRT1↑, *Inflam↓, *RAGE↓, *SOD2↑, *Catalase↑, *ROS↓, *PGC-1α↓, *BAX↓, *cl‑Casp3↓, *Bcl-2↑, *BDNF↑,
8220- LCA,    Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
- in-vivo, AD, NA
*Dose↝, *memory↑, *PSD95↑, *Ki-67↑, *GLUT1↑, *Aβ↓, *Aβ42↓, *Inflam↓, *TREM2↓, *cognitive↑,
8135- LF,    Lactoferrin-A Regulator of Iron Homeostasis and Its Implications in Cancer
- Review, Var, NA - Review, AD, NA
IronCh↑, ROS↓, Imm↑, Inflam↓, *BBB↑, Iron↝, *Fenton↓, *ROS↓, *TAC↑, *SOD↑, *GPx↑, *GSH↑, *TBARS↓, *PTEN↓, *tau↓, *MAPK↓, *Aβ42↓, *Apoptosis↓, *Casp3↓, *Akt↑, *GutMicro↑, *Sepsis↓, *anemia↓, *IL6↓, *FPN↑, *TfR1/CD71↑, *Ferritin↓, *HemoG↑, *RBC↑, *eff↑, *BioAv↓, *BioAv↑, *BioAv↝, *ChemoSen↑, *BioAv↑, Ferroptosis↑,
8144- LF,    A pilot study on the effect of lactoferrin on Alzheimer's disease pathological sequelae: Impact of the p-Akt/PTEN pathway
- Human, AD, NA
*Ach↑, *5HT↑, *TAC↑, *Inflam↓, *Akt↑, *PI3K↑, *Aβ42↓, *LDL↓, *ROS↓, *IL6↓, *HSP90↓, *Casp3↓, *tau↓, *MAPK↓, *PTEN↓, *cognitive↑, *Dose↝,
7825- LT,  MBS,    Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer's Disease: A Review
- Review, AD, NA
*neuroP↑, *OS↑, *antiOx↑, *Aβ42↓, *AChE↓, *Aβ↓, *IRes↓, *p‑tau↓, *ROS↓, *Apoptosis↓, *Inflam↓, *Iron↝,
8382- LT,    Luteolin as a dietary flavonoid for brain health: modulating neuroinflammation and cognitive decline in neurodegenerative disorders
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *NF-kB↓, *NRF2↑, *BDNF↑, *cognitive↑, *motorD↑, *BBB↑, *BioAv↓, *NO↓, *ROS↓, *NRF2↑, *ARE↑, *MMP↑, *BDNF↑, *Learn↑, *memory↑, *cognitive↑, *p‑JNK↓, *GFAP↓, *AIF1/Iba-1↓, *TNF-α↓, *IL1β↓, *BAX↓, *COX2/PTGS2↓, *BACE/β-secretase↓, *Aβ42↓, *PSD95↑, *SNAP25↑, *lipid-P↓, *GSTs↓, *GSH↑, *SOD↓, *Catalase↓, *AChE↓, *Casp3↓, *Casp9↓,
8399- LT,    Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *cognitive↑, *neuroP↑, *Aβ↓, *mtDam↓, *Apoptosis↓, *PPARγ↑, *ROS↓, *SOD↑, *GSH↑, *NRF2↑, *MFN2↑, *DRP1/DNM1L↓, *FIS1↓, *Bcl-2↑, *BAX↓, *Cyt‑c↓, *cl‑Casp9↓, *cl‑Casp3↓, *IDE↑, *BACE/β-secretase↓, *Aβ42↓,
8398- LT,    Luteolin: Nature's promising warrior against Alzheimer's and Parkinson's disease
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *AntiBio↑, *AntiCan↑, *hepatoP↑, *neuroP↑, *cardioP↑, *neuroG↑, *BBB↑, *ROS↓, *AChE↓, *p‑T-cadherin↓, *Aβ↓, *memory↑, *TNF-α↓, *IL1β↓, *MCP1/CCL2↓, *RANTES↓, *BioAv↑, *Half-Life↝, *toxicity↓, *BACE/β-secretase↓, *Aβ42↓, *COX2/PTGS2↓, *Bcl-2↓, *Casp3↓, *BAX↓, *GSTs↓, *lipid-P↓, *Casp3↓, *Casp9↓, *memory↑, *GSK‐3β↓, *ChAT↑, *SOD↑, *GPx↑, *MDA↓, *ER Stress↓, *GRP78/BiP↓, *NRF2↑, *motorD↑, *antiAll↑,
8421- Lyco,    Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease
- Review, AD, NA
*neuroP↑, *antiOx↑, *Inflam↓, *AntiMyl↑, *ROS↓, *MMP↑, *NGF↑, *BDNF↑, *VEGF↑, *Aβ42↓, *PI3K↑, *Akt↑, *NRF2↑, *lipid-P↓, *GSH↑, *Catalase↑, *SOD↑, *cognitive↑, *Learn↑, *memory↑, *APP↓, *BACE/β-secretase↓, *ADAM10↑, *NF-kB↓, *AChE↓, *MAOA↓, *BioAv↝,
8416- Lyco,    Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling
- in-vivo, AD, NA
*Inflam↓, *ROS↓, *Dose↝, *Aβ42↓, *IL1β↓, *TNF-α↓, *MDA↓, *Ach↑, *MAOA↓, *LDH↓, *AChE↓, *NRF2↑, *5HT↑, *TGF-β1↑, *IL10↑, *Ki-67↓, *PCNA↓,
8494- MAG,    Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*cognitive↑, *PSD95?, *SYN1↑, *SYT1↑, *IL10↑, *TNF-α↓, *IL6↓, *Aβ42↓, *GFAP↓, *other↑, *cognitive↑, *NeuroI↓, *Aβ↓, *GSK‐3β↓, *NF-kB↓,
8928- MBS,  VT,  IVT,    Neuroprotective activity of mung bean (Vigna radiata) coat extract via AMPK-dependent autophagy in Alzheimer's and Parkinson's models
- in-vitro, AD, NA - in-vitro, Park, NA
*Aβ42↓, *tau↓, *ROS↓, *motorD↑, *Ingr↝, *neuroP↑,
8467- Mg,    Magnesium L-Threonate Reduces Hippocampal Amyloid-β Load without Cognitive Improvement in a PTU-induced Hypothyroidism Model in Young Rats
- in-vivo, AD, NA
*cognitive∅, *BDNF↑, *Aβ42↓,
8914- MO,    Moringa oleifera Extracts as Strategic Phyto‐Therapy for Alzheimer's Disease
- in-vitro, AD, NA
*Aβ42↓, *mt-ROS↓,
8915- MO,    Therapeutic Potential of Moringa oleifera in Alzheimer’s Disease: A Review of Neuroprotective Mechanisms
- Review, AD, NA
*Ingr↝, *antiOx↑, *Inflam↓, *NRF2↑, *ARE↑, *AChE↓, *Aβ42↓, *cognitive↑, *BACE/β-secretase↓, *neuroP↑, *PI3K↑, *Akt↑, *mTOR↑, *Learn↑, *memory↑, *ATP↑, *SOD↑, *Catalase↑, *p‑tau↓,

Showing Research Papers: 1 to 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Iron↝, 1,   ROS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   Inflam↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   ARE↑, 2,   Catalase↓, 1,   Catalase↑, 3,   Fenton↓, 1,   GPx↑, 2,   GSH↑, 4,   GSTs↓, 2,   Iron↝, 1,   lipid-P↓, 3,   MDA↓, 2,   NRF2↑, 7,   ROS↓, 10,   mt-ROS↓, 1,   SOD↓, 1,   SOD↑, 5,   SOD2↑, 1,   TAC↑, 2,   TBARS↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FPN↑, 1,   TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

DRP1/DNM1L↓, 1,   FIS1↓, 1,   MFN2↑, 1,   mtDam↓, 1,   PGC-1α↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↑, 1,   GSK‐3β↓, 2,   LDL↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 3,   BAX↓, 4,   Bcl-2↓, 1,   Bcl-2↑, 2,   Casp3↓, 5,   cl‑Casp3↓, 2,   Casp9↓, 2,   cl‑Casp9↓, 1,   Cyt‑c↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 4,   p‑JNK↓, 1,   MAPK↓, 2,   mTOR↑, 1,   PI3K↑, 3,   PTEN↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP90↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,   Ki-67↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,   Ki-67↑, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

p‑T-cadherin↓, 1,   TGF-β1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↑, 1,   MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 1,   COX2/PTGS2↓, 2,   IL10↑, 2,   IL1β↓, 3,   IL6↓, 3,   Inflam↓, 9,   MCP1/CCL2↓, 1,   NeuroI↓, 1,   NF-kB↓, 4,   RAGE↓, 1,   RANTES↓, 1,   TNF-α↓, 4,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,   TREM2↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   Ach↑, 3,   AChE↓, 7,   ADAM10↑, 1,   BDNF↑, 5,   ChAT↑, 1,   MAOA↓, 2,   NGF↑, 1,   PSD95?, 1,   PSD95↑, 2,   SNAP25↑, 1,   SYN1↑, 1,   SYT1↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   APP↓, 1,   Aβ↓, 5,   Aβ42↓, 15,   BACE/β-secretase↓, 5,   IDE↑, 1,   tau↓, 3,   p‑tau↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 3,   BioAv↝, 2,   ChemoSen↑, 1,   Dose↝, 3,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

anemia↓, 1,   Ferritin↓, 1,   HemoG↑, 1,   IL6↓, 3,   IRes↓, 1,   LDH↓, 1,   RAGE↓, 1,   RBC↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiCan↑, 1,   AntiMyl↑, 1,   cardioP↑, 1,   cognitive↑, 9,   cognitive∅, 1,   hepatoP↑, 1,   Learn↑, 3,   memory↑, 7,   motorD↑, 3,   neuroP↑, 7,   OS↑, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   GutMicro↑, 1,   Sepsis↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 2,  
Total Targets: 131

Scientific Paper Hit Count for: Aβ42, Amyloid Beta 1-42
4 Luteolin
2 Lactoferrin/Talactoferrin
2 Mung Bean Sprouts
2 Lycopene
2 Moringa oleifera
1 L-Theanine
1 Licochalcone A
1 Magnolol
1 Vitexin
1 Isovitexin
1 Magnesium
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1706  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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