AIF1/Iba-1 Cancer Research Results

AIF1/Iba-1, Allograft Inflammatory Factor 1 / Ionized Calcium-Binding Adapter Molecule 1: Click to Expand ⟱
Source:
Type:

AIF1 - Allograft Inflammatory Factor 1 / Ionized Calcium-Binding Adapter Molecule 1

Abbreviation: AIF1, Iba-1, IBA1

Type: Calcium-binding protein / microglial and macrophage activation marker

Function: AIF1, commonly called Iba-1, is a calcium-binding cytoplasmic protein expressed predominantly in microglia and macrophage-lineage cells. It participates in cytoskeletal remodeling, membrane ruffling, phagocytosis, migration, inflammatory signaling, and immune-cell activation. Iba-1 immunostaining is widely used to identify microglia and assess changes in microglial abundance and activation state.

Cancer: ↑ / immune-microenvironment associated. Increased AIF1/Iba-1 commonly reflects infiltration or activation of tumor-associated macrophages and other myeloid cells. Elevated AIF1-positive immune-cell populations can be associated with inflammation, angiogenesis, invasion, immunosuppression, and tumor progression, although interpretation depends strongly on macrophage phenotype and tumor type.

Alzheimer's Disease: ↑ Increased Iba-1 expression and immunoreactivity are commonly observed in Alzheimer's disease and experimental AD models and reflect increased microglial activation and/or accumulation around amyloid plaques and sites of neuronal injury. Reduced Iba-1 following treatment is generally interpreted as reduced microgliosis or neuroinflammation, although Iba-1 alone does not distinguish protective from detrimental microglial states.
Scientific Papers found: Click to Expand⟱
7852- isoO,    Neuroprotection of isoorientin against microglia activation induced by lipopolysaccharide via regulating GSK3β, NF-κb and Nrf2/HO-1 pathways
- in-vitro, AD, NA
*GSK‐3β↓, *TNF-α↓, *COX2/PTGS2↓, *BDNF↑, *AIF1/Iba-1↓, *IκB↑, *HO-1↑, *NF-kB↓, *NRF2↑,
8382- LT,    Luteolin as a dietary flavonoid for brain health: modulating neuroinflammation and cognitive decline in neurodegenerative disorders
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *NF-kB↓, *NRF2↑, *BDNF↑, *cognitive↑, *motorD↑, *BBB↑, *BioAv↓, *NO↓, *ROS↓, *NRF2↑, *ARE↑, *MMP↑, *BDNF↑, *Learn↑, *memory↑, *cognitive↑, *p‑JNK↓, *GFAP↓, *AIF1/Iba-1↓, *TNF-α↓, *IL1β↓, *BAX↓, *COX2/PTGS2↓, *BACE/β-secretase↓, *Aβ42↓, *PSD95↑, *SNAP25↑, *lipid-P↓, *GSTs↓, *GSH↑, *SOD↓, *Catalase↓, *AChE↓, *Casp3↓, *Casp9↓,
8507- MAG,    Magnolol acts as a neurorestorative agent in an Aβ1‑42‑induced mouse model of Alzheimer's disease
- in-vivo, AD, NA
*Dose?, *cognitive↑, *Aβ↓, *NeuroI↓, *neuroP↑, *tau↓, *GFAP↓, *AIF1/Iba-1↓, *GSK‐3β↑, *SYP↑, *BDNF↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↓, 1,   GSH↑, 1,   GSTs↓, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 3,   ROS↓, 1,   SOD↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↓, 1,   GSK‐3β↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp9↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

IκB↑, 1,   p‑JNK↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

AIF1/Iba-1↓, 3,   COX2/PTGS2↓, 2,   IL1β↓, 1,   Inflam↓, 1,   NeuroI↓, 1,   NF-kB↓, 2,   TNF-α↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GFAP↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 4,   PSD95↑, 1,   SNAP25↑, 1,   SYP↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   Aβ42↓, 1,   BACE/β-secretase↓, 1,   tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   Dose?, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 3,   Learn↑, 1,   memory↑, 1,   motorD↑, 1,   neuroP↑, 2,  
Total Targets: 44

Scientific Paper Hit Count for: AIF1/Iba-1, Allograft Inflammatory Factor 1 / Ionized Calcium-Binding Adapter Molecule 1
1 isoorientin
1 Luteolin
1 Magnolol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1714  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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