IL13 Cancer Research Results

IL13, Interleukin-13: Click to Expand ⟱
Source:
Type:

IL-13 - Interleukin-13

Type: Type-2 cytokine / immune signaling protein

Function: IL-13 is a type-2 immune cytokine produced by cells including group 2 innate lymphoid cells (ILC2), Th2 lymphocytes, mast cells, and eosinophils. IL-13 signals primarily through a receptor complex containing IL-13Rα1 and IL-4Rα, activating JAK/STAT6 and related pathways. It regulates alternative macrophage activation, mucus production, fibrosis, tissue remodeling, allergic inflammation, and type-2 immune responses.

Cancer: ↑ Frequently increased or functionally activated in tumor-associated type-2 immune responses. IL-13 can promote immunosuppressive macrophage polarization, stromal remodeling, fibrosis, tumor-cell survival, migration, invasion, and metastasis through IL-13 receptor and STAT6 signaling. Its effects remain tumor- and immune-context dependent.

Alzheimer's Disease: ↕ Context-dependent. IL-13 can modulate microglial and macrophage activation toward alternative immune phenotypes and may reduce selected pro-inflammatory responses, but its effects on amyloid pathology, neuroinflammation, and neuronal function vary by model and disease stage.
Scientific Papers found: Click to Expand⟱
7929- H2,    Hydrogen-rich saline reduces airway remodeling via inactivation of NF-κB in a murine model of asthma
- in-vivo, Asthma, NA
*IL4↓, *IL5↓, *IL13↓, *TNF-α↓, *AirwayM↓, *MUC5AC↓, *COL3A1↓, *VEGF↓, *NF-kB↓, *Inflam↓, *antiAll↑,
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, *IL4↓, *IL13↓, *TNF-α↓, *CXCL15↓, *SOD↑, *MDA↓, *MPO↓, *ROS↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *toxicity↓, *Stroke↓, *Airway↓, *Neut↓, *Eos↓, *BALF-Lym↓, *BALF-Infl↓, *AirwayM↓, *antiAll↑,
7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *ROS↓, *TAC↑, *IgE↓, *Dose↝, *NLR↓, *IL4↓, *IL5↓, *IL13↓, *GM-CSF↓, *NO↓, *GPx↑, *Eos↓, *antiAll↑,
7933- H2,    Hydrogen inhalation ameliorates lung inflammation in mice with asthma
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *IL4↓, *IL5↓, *IL13↓, *IL10↑, *TGF-β1↑, *IgE↓, *MDA↓, *SOD↑, *Airway↓, *antiAll↑,
7934- H2,    Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
- in-vivo, Asthma, NA
*IgE↓, *antiOx↑, *Eos↓, *BALF-Infl↓, *IL5↓, *IL13↓, *CCL11↓, *antiAll↑,
8318- LIN,    Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity
- in-vitro, BC, T47D - NA, CRC, SW-620 - NA, Liver, HepG2
TumCCA↑, IFN-γ↓, IL13↓, IL2↓, IL4↓, IL6↓, TNF-α↓, Th1 response?,
9055- PatchO,    Patchouli oil ameliorates 5-fluorouracil-induced intestinal mucositis in rats via protecting intestinal barrier and regulating water transport
- in-vivo, Nor, NA
*Dose↝, *eff↑, *TNF-α↑, *IFN-γ↑, *IL13↑, *NF-kB↑, *MAPK↑, *ZO-1↑, *OCLN↑, *IBI↑, *Casp8↓, *Casp3↓, *Bcl-2↑, *Apoptosis↓, *BAX↓, *AQPs↓,
7939- TQ,    Effects of Nigella sativa and its constituents on inflammatory markers in ovalbumin-induced asthma model: a preclinical systematic review and meta-analysis
- Review, Asthma, NA
*IL4↓, *IL5↓, *IL13↓, *IL17↓, *IgE↓, *IFN-γ∅, *antiOx↑, *Inflam↓, *antiAll↑,
7940- TQ,    Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
- in-vivo, Asthma, NA
*Eos↓, *Th2↓, *IgE↓, *IgG1↓, *Inflam↓, *AirwayM↓, *IL4↓, *IL5↓, *IL13↓, *IFN-γ↑, *antiAll↑,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   IL13↓, 1,   IL2↓, 1,   IL4↓, 1,   IL6↓, 1,   Th1 response?, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   GPx↑, 1,   MDA↓, 2,   MPO↓, 1,   ROS↓, 2,   SOD↑, 2,   TAC↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 2,   BAX↓, 1,   Bcl-2↑, 1,   Casp3↓, 1,   Casp8↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

MAPK↑, 1,  

Migration(tgid=13) ⓘ

COL3A1↓, 1,   TGF-β1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   IBI↑, 1,   MUC5AC↓, 1,   OCLN↑, 1,   ZO-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

BALF-Infl↓, 2,   BALF-Lym↓, 1,   CCL11↓, 1,   CXCL15↓, 1,   Eos↓, 4,   GM-CSF↓, 1,   IFN-γ↑, 2,   IFN-γ∅, 1,   IgE↓, 5,   IgG1↓, 1,   IL10↑, 1,   IL13↓, 7,   IL13↑, 1,   IL17↓, 1,   IL4↓, 6,   IL5↓, 6,   Inflam↓, 6,   Neut↓, 1,   NF-kB↓, 1,   NF-kB↑, 1,   Th2↓, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,   Dose↝, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

NLR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Airway↓, 2,   AirwayM↓, 3,   antiAll↑, 7,   Stroke↓, 1,   toxicity↓, 1,  
Total Targets: 54

Scientific Paper Hit Count for: IL13, Interleukin-13
5 Hydrogen Gas
2 Thymoquinone
1 Linalool
1 Patchouli Oil (Pogostemon cablin)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1723  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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