CXCL15 Cancer Research Results

CXCL15, C-X-C Motif Chemokine Ligand 15: Click to Expand ⟱
Source:
Type:

CXCL15 - C-X-C Motif Chemokine Ligand 15 / Lungkine

Abbreviation: CXCL15, Lungkine

Species: Mouse (Mus musculus)

Type: CXC chemokine / inflammatory signaling protein

Human Equivalent: No established direct human ortholog.

Function: CXCL15 is a mouse CXC chemokine expressed particularly strongly by lung epithelial cells. It is secreted into airway spaces and functions as a chemoattractant for neutrophils, contributing to pulmonary inflammatory responses, innate immune-cell recruitment, and lung-specific immune signaling.

Experimental Interpretation: ↑ CXCL15 generally indicates increased pulmonary chemokine signaling and neutrophil recruitment in mouse models. Because humans do not have a confirmed direct CXCL15 ortholog, results should not be assigned directly to a human CXCL15 target.
Scientific Papers found: Click to Expand⟱
7925- H2,    Inhalation of hydrogen gas attenuates airway inflammation and oxidative stress in allergic asthmatic mice
- in-vivo, Asthma, NA
*Dose?, *IL4↓, *IL13↓, *TNF-α↓, *CXCL15↓, *SOD↑, *MDA↓, *MPO↓, *ROS↓, *antiOx↑, *Inflam↓, *Apoptosis↓, *toxicity↓, *Stroke↓, *Airway↓, *Neut↓, *Eos↓, *BALF-Lym↓, *BALF-Infl↓, *AirwayM↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 1,   AirwayM↓, 1,   BALF-Infl↓, 1,   BALF-Lym↓, 1,   CXCL15↓, 1,   Eos↓, 1,   IL13↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   MDA↓, 1,   MPO↓, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL4↓, 1,   Inflam↓, 1,   Neut↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose?, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 20

Scientific Paper Hit Count for: CXCL15, C-X-C Motif Chemokine Ligand 15
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1724  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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