IgE Cancer Research Results

IgE, Immunoglobulin E: Click to Expand ⟱
Source:
Type:

IgE

Full Name: Immunoglobulin E

Definition: IgE is an antibody isotype involved primarily in allergic immune responses and defense against certain parasites. IgE binds with high affinity to FcεRI receptors on mast cells and basophils.

Asthma relevance: IgE is a major mediator and biomarker of allergic asthma. Allergen-specific IgE binds FcεRI on mast cells and basophils. Subsequent allergen-mediated cross-linking triggers cellular activation and release of histamine, leukotrienes, prostaglandins, and inflammatory cytokines.

Elevated total or allergen-specific IgE is frequently measured in human asthma and in experimental allergic asthma models such as ovalbumin (OVA) and house dust mite (HDM) models.

Direction:
IgE ↑ = generally adverse in allergic asthma
IgE ↓ = generally beneficial when elevated as part of an allergic response

Common measurement contexts: Serum total IgE; plasma IgE; allergen-specific IgE; OVA-specific IgE; HDM-specific IgE

Typical pathway:
IL-4 / IL-13 ↑ → B-cell class switching ↑ → IgE ↑ → FcεRI activation ↑ → mast-cell / basophil degranulation ↑ → histamine + leukotrienes ↑ → bronchoconstriction and airway inflammation ↑



Scientific Papers found: Click to Expand⟱
7934- H2,    Hydrogen-generating silicon-based agent is effective in a mouse model of ovalbumin-induced allergic bronchial asthma
- in-vivo, Asthma, NA
*IgE↓, *antiOx↑, *Eos↓, *BALF-Infl↓, *IL5↓, *IL13↓, *CCL11↓,
7933- H2,    Hydrogen inhalation ameliorates lung inflammation in mice with asthma
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *IL4↓, *IL5↓, *IL13↓, *IL10↑, *TGF-β1↑, *IgE↓, *MDA↓, *SOD↑, *Airway↓,
7932- H2,    Hydrogen Gas Inhalation Alleviates Airway Inflammation and Oxidative Stress on Ovalbumin-Induced Asthmatic BALB/c Mouse Model
- in-vivo, Asthma, NA
*antiOx↑, *Inflam↓, *ROS↓, *TAC↑, *IgE↓, *Dose↝, *NLR↓, *IL4↓, *IL5↓, *IL13↓, *GM-CSF↓, *NO↓, *GPx↑, *Eos↓,
7926- H2,    Hydrogen gas inhalation enhances alveolar macrophage phagocytosis in an ovalbumin-induced asthma model
- in-vivo, Asthma, NA
*Dose↝, *Airway↓, *BALF-Infl↓, *Th2↓, *IL4↓, *IgE↓, *MDA↓, *SOD↑, *NF-kB↓, *NRF2↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Airway↓, 2,   BALF-Infl↓, 2,   CCL11↓, 1,   Eos↓, 2,   IgE↓, 4,   IL13↓, 3,   NLR↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   GPx↑, 1,   MDA↓, 2,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 2,   TAC↑, 1,  

Migration(tgid=13) ⓘ

TGF-β1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

GM-CSF↓, 1,   IL10↑, 1,   IL4↓, 3,   IL5↓, 3,   Inflam↓, 2,   NF-kB↓, 1,   Th2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 2,  
Total Targets: 24

Scientific Paper Hit Count for: IgE, Immunoglobulin E
4 Hydrogen Gas
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1736  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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