CYP51/14LDM Cancer Research Results

CYP51/14LDM, Lanosterol 14α-Demethylase: Click to Expand ⟱

Source:

Type:

CYP51A1 - Lanosterol 14α-Demethylase

Abbreviation: CYP51A1, CYP51, 14LDM, Lanosterol 14α-Demethylase

Type: Cytochrome P450 enzyme / cholesterol biosynthesis enzyme

Function: CYP51A1 catalyzes oxidative removal of the 14α-methyl group from lanosterol and related sterol intermediates during cholesterol biosynthesis. It is an evolutionarily conserved sterol-demethylating enzyme and is essential for normal sterol and membrane-lipid homeostasis.

Cancer: ↕ Context-dependent. CYP51A1 can support cholesterol and sterol synthesis in metabolically active tumor cells, but its expression and importance vary by cancer type, so no universal cancer-associated direction is appropriate.

Scientific Papers found: Click to Expand⟱

8015-

itraC,

Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth

vitro+vivo,

BCC,

HH↓, Dose↝, CYP51/14LDM↓, Gli1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

CYP51/14LDM↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Gli1↓, 1, HH↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CYP51/14LDM, Lanosterol 14α-Demethylase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells