AKR1C3/17β-HSD5/PGF Synthase Cancer Research Results

AKR1C3/17β-HSD5/PGF Synthase, Aldo-Keto Reductase Family 1 Member C3: Click to Expand ⟱
Source:
Type:

AKR1C3 - Aldo-Keto Reductase Family 1 Member C3

Abbreviation: AKR1C3, 17β-HSD5, PGF Synthase

Type: Aldo-keto reductase / hydroxysteroid dehydrogenase / prostaglandin-metabolizing enzyme

Function: AKR1C3 is an NADPH-dependent oxidoreductase involved in steroid hormone and prostaglandin metabolism. It converts weak androgen precursors into more active androgens, can convert estrone to estradiol, and reduces prostaglandin D2 to 11β-PGF2α. Through these activities, AKR1C3 regulates hormone-receptor signaling, prostaglandin signaling, cellular proliferation, and metabolic adaptation.

Cancer: ↑ Frequently overexpressed in multiple cancers and associated with enhanced proliferation, invasion, metastasis, tumor recurrence, and resistance to anticancer therapy. In hormone-dependent cancers, increased AKR1C3 can enhance local androgen and estrogen production and thereby activate androgen- or estrogen-receptor signaling. AKR1C3 inhibition can suppress tumor progression and restore treatment sensitivity in experimental models.
Scientific Papers found: Click to Expand⟱
8054- KAE,    Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway
- vitro+vivo, AD, NA
*AKR1B10↝, *MDA↓, *ROS↓, *GSH↑, *SOD↑, *GPx4↑, *NQO1↑, *xCT/SLC7A11↑, *NRF2↑, *HO-1↑, *cognitive↑, *Aβ↓, *p‑tau↓, *Ferroptosis↓, *AKR1C3/17β-HSD5/PGF Synthase↑, *AKR1B1/ALR2↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AKR1B1/ALR2↑, 1,   AKR1B10↝, 1,   AKR1C3/17β-HSD5/PGF Synthase↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↓, 1,   GPx4↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,   xCT/SLC7A11↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,  
Total Targets: 17

Scientific Paper Hit Count for: AKR1C3/17β-HSD5/PGF Synthase, Aldo-Keto Reductase Family 1 Member C3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1751  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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