AMT/GCST/T-protein Cancer Research Results

AMT/GCST/T-protein, Aminomethyltransferase / Glycine Cleavage System T-Protein: Click to Expand ⟱
Source:
Type:

AMT - Aminomethyltransferase / Glycine Cleavage System T-Protein

Abbreviation: AMT, GCST, T-Protein

Type: Mitochondrial enzyme / glycine cleavage system component / one-carbon metabolism enzyme

Function: AMT is the T-protein component of the mitochondrial glycine cleavage system. It transfers the aminomethyl group generated during glycine cleavage to tetrahydrofolate, producing 5,10-methylenetetrahydrofolate and ammonia. Through this reaction, AMT connects glycine metabolism with mitochondrial one-carbon metabolism, folate metabolism, nucleotide synthesis, and cellular redox and biosynthetic pathways.

Cancer: ↕ Context-dependent. AMT and the glycine cleavage system can be highly expressed in cancers with increased mitochondrial glycine and one-carbon metabolism, including hepatocellular and renal cancers, potentially supporting biosynthesis and tumor growth. However, reduced AMT expression has been reported in colorectal cancer, where higher AMT expression was associated with improved survival. Therefore, AMT should not be assigned a universal oncogenic direction across cancers.
Scientific Papers found: Click to Expand⟱
8081- KAE,    The Anticancer Effects and Therapeutic Potential of Kaempferol in Triple-Negative Breast Cancer
- Review, BC, NA
*antiOx↓, *Inflam↓, *neuroP↓, *AntiCan↑, DNAdam↓, Casp3↑, Casp9↑, p‑AMT/GCST/T-protein↑, ROS↑, NRF2↑, Apoptosis↑, cl‑PARP↓, BAX↑, Bcl-2↓, TumCCA↓, angioG↓, MMP3↓, MMP9↓, ChemoSen↑, BioAv↓, Glycolysis↓, cl‑PARP↑, Ca+2↑, MMP↓, ER Stress↑, GRP78/BiP↑, CHOP/DDIT3↑, ATF6↑, angioG↓, VEGF↓, Hif1a↓, chemoP↑, *ROS↓, NRF2↑, BioAv↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 2,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   cl‑PARP↓, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   MMP3↓, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   ROS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   neuroP↓, 1,  
Total Targets: 5

Scientific Paper Hit Count for: AMT/GCST/T-protein, Aminomethyltransferase / Glycine Cleavage System T-Protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1758  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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