NMDAR Cancer Research Results

NMDAR, NMDA Receptor: Click to Expand ⟱
Source:
Type:

Phosphorylated NMDA Receptor - p-NMDAR

Abbreviation: p-NMDAR

Type: Receptor phosphorylation state / signaling biomarker

Function: NMDA receptor phosphorylation regulates receptor trafficking, channel activity, synaptic localization, calcium conductance, and synaptic plasticity. The biological effect depends on the NMDA receptor subunit and phosphorylation site measured.

Alzheimer's Disease: ↕ Dysregulated. NMDA receptor phosphorylation and trafficking are altered in Alzheimer's disease. Physiological phosphorylation of GluN2-containing NMDA receptors can support synaptic signaling and long-term potentiation, whereas excessive or aberrant NMDA receptor activation and phosphorylation can contribute to excitotoxicity. Interpretation therefore requires the specific subunit and phosphorylation site.
Scientific Papers found: Click to Expand⟱
8084- KAE,    Kaempferol treatment ameliorates memory impairments in STZ‑induced neurodegeneration by acting on reelin signaling
- in-vivo, AD, NA
*Learn↑, *memory↑, *GAD1/GAD67↑, *RELN↑, *p‑NMDAR↑, *neuroP↑,
8472- Mg,    Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model
- in-vivo, AD, NA
*Aβ↓, *memory↑, *eff↑, *NMDAR↑, *BACE/β-secretase↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GAD1/GAD67↑, 1,   Learn↑, 1,   NMDAR↑, 1,   p‑NMDAR↑, 1,   RELN↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

memory↑, 2,   neuroP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: NMDAR, NMDA Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1761  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page