APOE4 Cancer Research Results

APOE4, Apolipoprotein E ε4 Allele / ApoE4 Isoform: Click to Expand ⟱
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Type:

APOE4 - Apolipoprotein E ε4 Allele / ApoE4 Isoform

Canonical Gene: APOE

Abbreviation: APOE4, APOE ε4, ApoE4

Type: Genetic variant / protein isoform / Alzheimer's disease risk factor

Function: APOE encodes apolipoprotein E, a lipid-transport protein involved in cholesterol trafficking, neuronal maintenance, synaptic repair, immune regulation, and cerebrovascular function. The APOE ε4 allele produces the ApoE4 isoform, which differs structurally and functionally from ApoE2 and ApoE3.

Alzheimer's Disease: ↑ APOE ε4 is the strongest common genetic risk factor for late-onset Alzheimer's disease. ApoE4 promotes amyloid-β accumulation and impaired clearance, tau pathology, neuroinflammation, lipid and cholesterol dysregulation, mitochondrial dysfunction, synaptic impairment, blood-brain barrier dysfunction, and increased neuronal vulnerability.

Favorable Direction in Alzheimer's Disease: ↓ ApoE4-associated pathogenic activity or conversion toward a more ApoE3-like functional state is generally favorable. APOE ε4 carriage itself is a fixed genetic factor, so therapeutic strategies typically target ApoE4 expression, structure, lipidation, receptor interactions, or downstream pathways rather than reducing the allele itself.

Cancer: ↕ Context-dependent. APOE can influence tumor immunity, lipid metabolism, angiogenesis, and tumor-microenvironment interactions, but APOE ε4 is not a consistent universal cancer-promoting or cancer-suppressing factor across malignancies.
Scientific Papers found: Click to Expand⟱
8149- lamb,    Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCD↑, TumCCA↑, AMPK↑, Akt↓, FOXM1↓, Bcl-2↓, CycB/CCNB1↓, APOE4↑,
8145- LF,    Neuroprotective Effects of Lactoferrin in Alzheimer's and Parkinson's Diseases: A Narrative Review
- Review, AD, NA - Review, Park, NA
*AntiBio↑, *Imm↑, *AntiCan↑, *neuroP↑, *BBB↑, *APOE4↓, *ROS↓, *Inflam↓, *Apoptosis↓, *Learn↑, *memory↑, *ADAM10↑, *PSEN1/PS1↑, *cl‑APP↑, *BACE/β-secretase↓, *cognitive↑, *MDA↓, *IL6↓, *TNF-α↓, *neuroP↑, *Dose↝, *IronCh↑, *SOD↑, *BioAv↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

APOE4↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Bcl-2↓, 1,   TumCD↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

FOXM1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

FOXM1↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   APOE4↓, 1,   Learn↑, 1,   PSEN1/PS1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

MDA↓, 1,   ROS↓, 1,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

Migration(tgid=13) ⓘ

cl‑APP↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10↑, 1,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 2,  
Total Targets: 24

Scientific Paper Hit Count for: APOE4, Apolipoprotein E ε4 Allele / ApoE4 Isoform
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1765  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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