M2 MC Cancer Research Results

M2 MC, M2 macrophage conversion: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
M2 macrophages (M2 MC) are a subtype of macrophages that are generally associated with anti-inflammatory responses, tissue repair, and the promotion of tumor growth.
Strategies to reprogram M2 macrophages into a more pro-inflammatory M1 phenotype or to inhibit their function are being explored in cancer therapies.
M2 macrophages can play a dual role, promotion/suspression.
M2 macrophages are a subtype of macrophages that are generally associated with anti-inflammatory responses, tissue repair, and the promotion of tumor growth. The conversion of macrophages from the M1 (pro-inflammatory) to the M2 (anti-inflammatory) phenotype is a critical process in the tumor microenvironment and has significant implications for cancer progression.

M2 macrophages are generally considered protumorigenic. They secrete various cytokines and growth factors that promote tumor cell proliferation, angiogenesis, and tissue remodeling. Additionally, they can suppress the activity of cytotoxic T cells and natural killer (NK) cells, further aiding tumor immune evasion.
Scientific Papers found: Click to Expand⟱
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, Synergy↑, Synergy↑, Synergy↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
2793- CHr,    Chrysin Inhibits TAMs-Mediated Autophagy Activation via CDK1/ULK1 Pathway and Reverses TAMs-Mediated Growth-Promoting Effects in Non-Small Cell Lung Cancer
- in-vitro, Lung, A549 - in-vitro, Lung, H157 - in-vivo, NA, NA
TumCG↓, M2 MC↑, CDK1↓,
1577- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet
- in-vivo, PC, NA - in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988 - in-vitro, PC, MIA PaCa-2
Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
Synergy↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
6981- Form,    Formononetin: a review of its source, pharmacology, drug combination, toxicity, derivatives, and drug delivery systems
- Review, Var, NA - Review, AD, NA - Review, PSA, NA
BioAv↝, *memory↑, *ROS↓, *AChE↓, *NF-kB↓, *Keap1↝, *NRF2↑, *Inflam↓, *PGC-1α↝, *HO-1↓, *p‑tau↓, *cognitive↑, *BDNF↑, *5HT↑, *Stroke↓, *PARP1↓, *AIF↓, *Casp3↓, NP/CIPN↓, *neuroP↑, *NGF↑, *TNF-α↓, *IL1β↓, *IL18↓, *IL6↓, *VCAM-1↓, *pol-M2 MC↑, *hepatoP↑, *AST↓, *ALAT↓, *LC3II↑, *Beclin-1/ATG6↑, *p62↑, *COX2/PTGS2↑, *MMP↑, *ATP↑, *GSH↑, *Catalase↑, *GPx↑, *MDA↓, *antiPs↑, *AntiDiabetic↑, *glucose↓, *Insulin↑, *GutMicro↑, *Obesity↓, COX2/PTGS2↓, cycD1/CCND1↓, TumCCA↑, EGFR↓, GSK‐3β↑, Mcl-1↓, *toxicity↓, TumCP↓, Hif1a↓, VEGF↓, ERK↓, LAMs↓, Cyt‑c↑, Casp9↑, Casp3↑, PARP↑, TumCD↑, mitA↑, BACH1↓, P53↓, ROS↑, PD-1↓, NF-kB↓, *Bacteria↓, *AntiViral↑, *mt-ROS?, *PI3K↓, *chemoP↑, ChemoSen↑, Synergy↑, *toxicity↓, *BioAv↑, *BioAv↑, *Synergy↑, *antiAll↑,
7251- Gink,    Ginkgetin: A Promising Multitarget Agent for Diverse Diseases
- Review, Var, NA
*Inflam↓, *antiOx↓, AntiCan↑, *neuroP↑, *cardioP↑, *Bacteria↓, *ROS↓, *lipid-P↓, *NRF2↓, *Keap1↓, *NF-kB↓, *MAPK↓, MMP2↓, M2 MC↓, JAK2↓, STAT3↓, TumCP↓, Casp↑, ChemoSen↑, *BMD↑, *Aβ↓, *Stroke↓, *BioAv↓,
7489- H2,    Molecular Hydrogen in the Treatment of Respiratory Diseases
- Review, Asthma, NA
*antiOx↑, *Inflam↓, *Apoptosis↓, *Dose↓, *Dose↝, *eff↑, *ROS↓, *RNS↓, *NRF2↑, *HO-1↑, *Fenton↓, *NLRP3↓, *NADPH↓, *NOX4↓, *NOX↓, *MPO↓, *NF-kB↓, *TNF-α↓, *IL6↓, *IL1β↓, *HMGB1↓, *IL4↑, *IL10↑, *M2 MC↑, *Treg lymp↝, *Bcl-2↑, *Bcl-xL↑, *PI3K↑, *Akt↑, *JAK2↑, *STAT3↑, *Dose↑, *CD4+↑, *CD25+↑, *FOXP3↑, *MDA↓, *SOD↑, *Catalase↑, *Casp3↓, *Casp9↓, *TBARS↓, *SpO2↑, *VitE↓, *OS↑, *Weight↑, *DNAdam↓, *PGE2↓, *MCP1/CCL2↓, *lipid-P↓, *TumCP↓, *tumCV↓, *TumCMig↓, *TumCI↓, TumW↓, TumVol↓, selectivity↑, QoL↑, ChemoSen↑, chemoP↑, radioP↑, ROS↑, NLRP3↑, Casp3↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, *antiAll↑,
7776- IBC,    Isobavachalcone Activates Antitumor Immunity on Orthotopic Pancreatic Cancer Model: A Screening and Validation
- vitro+vivo, PC, Panc02
TumCP↓, Apoptosis↑, ROS↑, TumW↓, CD8+↑, M2 MC↓, CSCs↓, antiNeop↑, Imm↑, eff↓, Bcl-2↓, BAX↑,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
8339- LDN,    Low-dose naltrexone inhibits the epithelial-mesenchymal transition of cervical cancer cells in vitro and effects indirectly on tumor-associated macrophages in vivo
- in-vivo, Cerv, HeLa
TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, TAMS↓, M2 MC↓, IL10↓, OGFr↑, chemoP↑,
8387- LT,  QC,  Api,  Ba,    Identification of Flavonoid Compounds in Treating Alzheimer's Disease Based on Network Medicine Framework Strategy
- in-vitro, AD, NA
*neuroP↑, *MMP↑, *Apoptosis↓, *Akt↓, *NF-kB↓, *pol-M2 MC↑, *NeuroI↓,
4532- MAG,  Cisplatin,    Magnolol Attenuates Cisplatin-Induced Muscle Wasting by M2c Macrophage Activation
- in-vivo, Var, NA
cachexia↓, *IGF-1↑, chemoP↑, *M2 MC↑,
8816- MCP,    Modified citrus pectin inhibits breast cancer development in mice by targeting tumor-associated macrophage survival and polarization in hypoxic microenvironment
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, 4T1
GlucoseCon↓, GLUT1↓, Gal-3↓, ROS↓, NRF2↓, Hif1a↓, angioG↓, pol-M2 MC↓, p‑STAT3↓, TumCG↓, TumW↓,
116- Myrrh,    The Role of Myrrh Metabolites in Cancer, Inflammation, and Wound Healing: Prospects for a Multi-Targeted Drug Therapy
- in-vitro, AML, HL-60 - in-vitro, AML, K562 - in-vitro, BC, KAIMRC1
ROS↑, M1↑, M2 MC↑, Apoptosis?, BBB↝,

Showing Research Papers: 1 to 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↓, 1,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 7,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   mitResp↓, 1,   mtDam↑, 1,   OCR↓, 1,   OXPHOS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   ATP↓, 1,   ATP↑, 1,   i-ATP↑, 1,   ECAR↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 4,   GSK‐3β↑, 1,   lactateProd↓, 1,   PKM2↓, 1,   PKM2↑, 1,   SIRT1↑, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis?, 1,   Apoptosis↑, 4,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp3↑, 2,   Casp9↑, 1,   Cyt‑c↑, 3,   DR5↑, 2,   FADD↑, 1,   Fas↑, 2,   Ferroptosis↑, 1,   Mcl-1↓, 2,   p38↑, 1,   Pyro↑, 1,   TumCD↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 1,   ERK↓, 1,   ERK↑, 1,   JAK2↓, 1,   JNK↑, 2,   MAPK↓, 1,   mTOR↓, 2,   PI3K↓, 2,   STAT3↓, 2,   p‑STAT3↓, 2,   STAT5↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HDAC↓, 1,   OCT4↓, 1,   SOX4↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   ER Stress↑, 3,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↑, 2,   LAMP2↑, 1,   p62↑, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↓, 1,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK2↓, 1,   CDK4↓, 1,   CDK6↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↓, 1,   mitA↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 2,   HH↓, 1,   IGF-1↓, 2,   Ki-67↓, 1,   Nanog↓, 1,   OGFr↑, 1,   TumCG↓, 3,   TumCG↑, 1,   TumCP↓, 6,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AXL↓, 1,   BACH1↓, 1,   Ca+2↑, 2,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   EMT↓, 2,   LAMs↓, 1,   MMP2↓, 2,   MMP9↓, 2,   Slug↓, 1,   Snail?, 1,   SPARC↑, 1,   TGF-β↓, 1,   TIMP2↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↓, 1,   uPA↓, 1,   Zeb1↓, 1,   ZEB2↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   Hif1a↓, 3,   VEGF↓, 4,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↝, 1,   GLUT1↓, 2,   MMP↓, 1,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   CD8+↑, 2,   COX2/PTGS2↓, 2,   DR4↑, 1,   Gal-3↓, 1,   IL10↓, 1,   IL4↓, 1,   Imm↑, 1,   Imm↝, 1,   M1↑, 1,   pol-M1↑, 1,   M2 MC↓, 7,   M2 MC↑, 2,   pol-M2 MC↓, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 1,   NLRP3↑, 1,   p65↓, 1,   PD-1↓, 1,   Treg lymp↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

TAMS↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

PPARγ↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 7,   Dose↝, 1,   eff↓, 2,   eff↑, 4,   MDR1↓, 1,   RadioS↑, 1,   selectivity↑, 2,   Synergy↑, 6,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 2,   EGFR↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 2,   cachexia↓, 1,   chemoP↑, 3,   ChemoSideEff↓, 1,   NP/CIPN↓, 1,   QoL↑, 2,   radioP↑, 1,   toxicity∅, 1,   TumVol↓, 1,   TumW↓, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 164

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 2,   Catalase↑, 2,   Fenton↓, 1,   GPx↑, 1,   GPx4↑, 1,   GSH↑, 1,   HO-1↓, 1,   HO-1↑, 1,   i-Iron↓, 1,   Keap1↓, 1,   Keap1↝, 1,   lipid-P↓, 2,   MDA↓, 3,   MPO↓, 1,   NOX↓, 1,   NOX4↓, 1,   NRF2↓, 1,   NRF2↑, 3,   RNS↓, 1,   ROS↓, 4,   mt-ROS?, 1,   SOD↑, 1,   TBARS↓, 1,   VitE↓, 1,   xCT/SLC7A11↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 1,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↑, 1,   glucose↓, 1,   NADPH↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↓, 1,   Apoptosis↓, 2,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 2,   Casp9↓, 1,   Ferroptosis↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   Akt↑, 1,   JAK2↑, 1,   MAPK↓, 1,   PI3K↓, 1,   PI3K↑, 1,   STAT3↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   PARP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↑, 1,   TumCP↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VCAM-1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD25+↑, 1,   CD4+↑, 1,   COX2/PTGS2↑, 1,   FOXP3↑, 1,   HMGB1↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 2,   IL4↑, 1,   IL6↓, 2,   Inflam↓, 3,   M2 MC↑, 2,   pol-M2 MC↑, 2,   MCP1/CCL2↓, 1,   NeuroI↓, 1,   NF-kB↓, 4,   NLRP3↓, 1,   PGE2↓, 1,   TNF-α↓, 2,   Treg lymp↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 1,   BDNF↑, 1,   NGF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   p‑tau↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BMD↑, 1,   IL6↓, 2,   SpO2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiDiabetic↑, 1,   antiPs↑, 1,   cardioP↑, 1,   chemoP↑, 1,   cognitive↑, 1,   hepatoP↑, 1,   memory↑, 1,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 1,   Stroke↓, 2,   toxicity↓, 3,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,   GutMicro↑, 2,  
Total Targets: 113

Scientific Paper Hit Count for: M2 MC, M2 macrophage conversion
2 diet FMD Fasting Mimicking Diet
1 Artemisinin
1 Chrysin
1 Citric Acid
1 Chemotherapy
1 Formononetin
1 Ginkgetin
1 Hydrogen Gas
1 Isobavachalcone
1 Kaempferol
1 low dose naltrexone
1 Luteolin
1 Quercetin
1 Apigenin (mainly Parsley)
1 Baicalein
1 Magnolol
1 Cisplatin
1 Modified Citrus Pectin
1 Myrrh
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:177  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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