CYP2C19 Cancer Research Results

CYP2C19, Cytochrome P450 Family 2 Subfamily C Member 19: Click to Expand ⟱
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CYP2C19 - Cytochrome P450 Family 2 Subfamily C Member 19

Abbreviation: CYP2C19

Type: Cytochrome P450 monooxygenase / drug-metabolizing enzyme / xenobiotic metabolism enzyme / pharmacogenetic target

Function: CYP2C19 is an endoplasmic-reticulum cytochrome P450 enzyme expressed primarily in the liver and, to a lesser extent, the intestine. It oxidizes numerous xenobiotics, drugs and endogenous substrates and contributes to phase I metabolism, drug clearance and metabolic activation or inactivation.

Drug and Compound Metabolism: ↕ CYP2C19 activity can increase or decrease the biological effect of a compound depending on whether metabolism inactivates the parent compound, produces an active metabolite, or activates a prodrug.

Pharmacogenetics: CYP2C19 activity varies substantially between individuals. Loss-of-function alleles such as CYP2C19*2 and CYP2C19*3 can produce reduced or poor metabolism, while CYP2C19*17 is associated with increased expression and activity.

Cancer: ↕ Context-dependent. CYP2C19 does not have a universal favorable cancer direction. Its importance is primarily determined by the substrate or anticancer agent being metabolized and whether CYP2C19-mediated metabolism activates, inactivates or clears that compound.

Interpretation Note: When a natural product or drug inhibits CYP2C19, record CYP2C19 activity ↓ rather than assuming this is beneficial or harmful. The biological consequence depends on the affected substrate and its metabolites.
Scientific Papers found: Click to Expand⟱
8217- LCA,    Inhibition of human cytochrome P450 enzymes by licochalcone A, a naturally occurring constituent of licorice
- Study, Nor, NA
*CYP1A1↓, *CYP2C19↓, *CYP2C8↓, *CYP2C9↓, *CYP3A4↓, *CYP2E1↓, *CYP2D6↓, *BioEnh↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

CYP2C19↓, 1,   CYP2C8↓, 1,   CYP2D6↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

CYP1A1↓, 1,   CYP2E1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CYP3A4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioEnh↑, 1,   CYP2C9↓, 1,  
Total Targets: 8

Scientific Paper Hit Count for: CYP2C19, Cytochrome P450 Family 2 Subfamily C Member 19
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1780  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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