SYN3 Cancer Research Results

SYN3, Synapsin III: Click to Expand ⟱
Source:
Type:

SYN3 - Synapsin III

Abbreviation: SYN3, Synapsin III

Type: Neuronal phosphoprotein / synaptic vesicle-associated protein / neurodevelopmental regulator

Function: Synapsin III is a neuron-enriched phosphoprotein involved in neurogenesis, axonogenesis, neurotransmitter release, dopaminergic signaling, and regulation of synaptic vesicle function. Compared with Synapsin I and II, SYN3 has particularly important roles during early neuronal development and is also found at extrasynaptic sites such as neuronal cell bodies and growth cones.

Alzheimer's Disease: ↓ SYN3 expression has been reported in hippocampal CA1 pyramidal neurons in mild cognitive impairment and Alzheimer's disease, consistent with impaired presynaptic and synaptic function.

Favorable Direction in Alzheimer's Disease: ↑ Restoration or preservation of normal SYN3 expression/function may be favorable where reduced SYN3 reflects synaptic dysfunction.

Cancer: ↕ Context-dependent. In glioblastoma, SYN3 has demonstrated tumor-suppressive activity. SYN3 expression is reduced in glioblastoma relative to normal tissue and other glioma subtypes, while experimental SYN3 overexpression reduces glioblastoma stem-cell proliferation and stemness and promotes neuronal-like differentiation.

Favorable Direction in Glioblastoma: ↑ SYN3 expression/activity appears favorable based on current experimental evidence.
Scientific Papers found: Click to Expand⟱
8227- LCA,    Licochalcone A as Novel Multitarget Inhibitors via AChE, BuChE, and Synapsin III for Therapeutic Intervention Against Alzheimer’s Disease: Computer-Aided Drug Design
- Study, AD, NA
*AChE↓, *BChE↓, *SYN3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

SYN3↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BChE↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: SYN3, Synapsin III
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1783  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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