FBXO5/EMI1 Cancer Research Results

FBXO5/EMI1, F-Box Protein 5 / Early Mitotic Inhibitor 1: Click to Expand ⟱
Source:
Type:

FBXO5 - F-Box Protein 5 / Early Mitotic Inhibitor 1

Abbreviation: FBXO5, EMI1

Type: Cell-cycle regulator / APC/C inhibitor / F-box family protein

Function: FBXO5/EMI1 inhibits the anaphase-promoting complex/cyclosome (APC/C), preventing premature degradation of cell-cycle proteins during S and G2 phases and helping regulate entry into and progression through mitosis.

Cancer: ↑ FBXO5 is frequently overexpressed in solid tumors and can promote proliferation, migration, invasion, chromosomal instability and tumor progression. High FBXO5 expression has been associated with poor prognosis in multiple cancer types.

Favorable Direction in Cancer: ↓ FBXO5 expression or activity is generally favorable where FBXO5 functions as an oncogenic cell-cycle regulator.
Scientific Papers found: Click to Expand⟱
8233- LCA,    Licochalcone A induces cell cycle arrest and apoptosis via suppressing MAPK signaling pathway and the expression of FBXO5 in lung squamous cell cancer
- in-vitro, Lung, NA
TumCP↓, selectivity↑, TumCCA↑, Apoptosis↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, BAX↑, PARP1↑, Casp3↑, Bcl-2↓, MAPK↓, FBXO5/EMI1↓, TumVol↓, TumW↓, toxicity↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

FBXO5/EMI1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   MAPK↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP1↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: FBXO5/EMI1, F-Box Protein 5 / Early Mitotic Inhibitor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1784  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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