miR-326-5p Cancer Research Results

miR-326-5p, MicroRNA-326-5p: Click to Expand ⟱
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miR-326-5p - MicroRNA-326-5p

Abbreviation: miR-326-5p, miR-326

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-326-5p is a mature microRNA derived from MIR326 that regulates gene expression by binding complementary sequences in target mRNAs, promoting mRNA degradation or translational repression. It participates in regulation of proliferation, apoptosis, differentiation, inflammation, metabolism, and oncogenic signaling.

Cancer: ↓ miR-326-5p is reduced in several cancers and most commonly functions as a tumor-suppressive microRNA. Restoration of miR-326-5p can inhibit cancer-cell proliferation, migration and invasion and promote apoptosis by suppressing oncogenic targets such as PNO1, ITGA5 and other context-dependent targets.

Favorable Direction in Cancer: ↑ Restoration of miR-326-5p is generally favorable where it functions as a tumor-suppressor miRNA.

Alzheimer's Disease: ↓ / insufficient miR-326 activity may be unfavorable. Experimental miR-326 overexpression reduced VAV1 expression, JNK signaling, tau phosphorylation, neuronal apoptosis, Aβ deposition, and Aβ40/Aβ42 levels and improved cognitive performance in an Alzheimer's disease mouse model.

Favorable Direction in Alzheimer's Disease: ↑ miR-326 activity appears favorable based on experimental evidence.

Interpretation Note: Some older studies report “miR-326” without distinguishing the 5p and 3p mature strands. When a paper specifically measures miR-326-5p, record it as miR-326-5p rather than assuming all historical miR-326 findings are strand-specific.
Scientific Papers found: Click to Expand⟱
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-122-5p↑, 1,   miR-195↑, 1,   miR-199↑, 1,   miR-326-5p↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlutaM↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PKM2↓, 1,   PPP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

miR-206↑, 1,   miR-221↑, 1,   miR-222↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   miR-126↑, 1,   miR-34b-5p↑, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-326-5p, MicroRNA-326-5p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1797  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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