TBXAS1/TxAS Cancer Research Results

TBXAS1/TxAS, Thromboxane A Synthase 1: Click to Expand ⟱

Source:

Type:

TBXAS1 - Thromboxane A Synthase 1

Abbreviation: TBXAS1, TxAS, TXAS, TXA2S, CYP5A1

Type: Cytochrome P450-family enzyme / eicosanoid biosynthesis enzyme / thromboxane synthase

Function: TBXAS1 catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a short-lived bioactive eicosanoid that promotes platelet activation, vasoconstriction, cell signaling, and inflammatory responses.

Cancer: ↑ TBXAS1 expression and thromboxane synthesis are increased in several cancers and can promote tumor-cell proliferation, migration, invasion, angiogenesis, metastasis, and tumor-microenvironment signaling.

Favorable Direction in Cancer: ↓ TBXAS1 expression or activity is generally favorable where thromboxane signaling contributes to tumor progression.

Pathway Relationship: Arachidonic Acid → COX-1/COX-2 → PGH2 → TBXAS1 ↑ → TXA2 ↑ → TBXA2R/TP signaling ↑.

Interpretation Note: TBXAS1/TxAS is the enzyme that synthesizes TXA2 and should be kept separate from TXA2 itself and from its receptor TBXA2R/TP.

Scientific Papers found: Click to Expand⟱

8289-

LE,

Cisplatin,

Effects of Glycyrrhizin in a Mouse Model of Lung Adenocarcinoma

vitro+vivo,

Lung,

TBXAS1/TxAS↓, PCNA↓, Weight?, RenoP↑, hepatoP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

TBXAS1/TxAS↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1, RenoP↑, 1, Weight?, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TBXAS1/TxAS, Thromboxane A Synthase 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells