GSTM1 Cancer Research Results

GSTM1, Glutathione S-Transferase Mu 1: Click to Expand ⟱
Source:
Type:

GSTM1 - Glutathione S-Transferase Mu 1

Abbreviation: GSTM1, GST Mu 1

Type: Phase II detoxification enzyme / glutathione transferase / antioxidant and xenobiotic metabolism enzyme

Function: GSTM1 catalyzes conjugation of reduced glutathione to electrophilic compounds, facilitating detoxification and elimination of carcinogens, environmental toxins, therapeutic drugs, and reactive products of oxidative stress.

Cancer: ↕ Context-dependent. Normal GSTM1 activity can protect against carcinogenesis by detoxifying reactive carcinogens and oxidative products, and the GSTM1-null genotype has been associated with increased susceptibility to several cancers. However, in established tumors, GSTM1-mediated detoxification can also protect cancer cells from oxidative stress and anticancer drugs and may contribute to treatment resistance.

Favorable Direction in Cancer: Context-dependent. ↑ GSTM1 activity may be protective during cancer prevention by increasing carcinogen detoxification, whereas ↓ GSTM1 activity may enhance sensitivity to certain chemotherapies in established tumors.

Genetic Relevance: A common homozygous deletion produces the GSTM1-null genotype, resulting in absence of functional GSTM1 enzyme activity. This polymorphism can modify susceptibility to environmental carcinogens and alter drug response.

Interpretation Note: Distinguish GSTM1 expression/activity from GSTM1 genotype. “GSTM1-null” means the gene is deleted and enzyme activity is absent; it is not simply reduced expression.
Scientific Papers found: Click to Expand⟱
8295- lign,    Distribution, biosynthesis and therapeutic potential of lignans
- Review, Var, NA
*Ingr?, *BioAv↝, *antiOx↑, *AntiCan↑, *Inflam↓, *other?, Dose↝, AntiTum↑, pS2/TFF1↓, Bcl-2↓, IGF-1R↓, *radioP↑, *HO-1↑, GSTM1↑, NQO1↑, ChemoSen↑, *AntiDiabetic↑, *glucose↓, *GSH↑, *SOD↑, *MDA↓, *NO↓, *Bacteria↓, *AntiFungal↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

GSTM1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

NQO1↑, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   pS2/TFF1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1R↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Ingr?, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

glucose↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 1,   radioP↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: GSTM1, Glutathione S-Transferase Mu 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1800  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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