GPER Cancer Research Results

GPER, G Protein-Coupled Estrogen Receptor 1: Click to Expand ⟱
Source:
Type:

GPER1 - G Protein-Coupled Estrogen Receptor 1

Abbreviation: GPER1, GPER, GPR30

Alternative Names: G Protein-Coupled Estrogen Receptor, GPR30, Membrane Estrogen Receptor

Type: G protein-coupled receptor / membrane-associated estrogen receptor / steroid hormone signaling receptor

Function: GPER1 mediates rapid non-genomic and transcriptional responses to estrogens and other ligands. Activation can stimulate cAMP production, intracellular calcium mobilization, PI3K/AKT signaling, MAPK/ERK signaling, phospholipase C signaling, and EGFR transactivation.

Cancer: ↕ Context-dependent. GPER1 activation can promote proliferation, migration, invasion, metastasis, cancer stem-cell activity, angiogenic signaling, and endocrine resistance in several cancers, particularly hormone-responsive tumors. However, selective GPER activation can also inhibit proliferation or induce antitumor responses in some experimental models.

Favorable Direction in Cancer: Context-dependent. ↓ GPER1 signaling may be favorable where GPER1 promotes tumor growth or endocrine resistance, whereas ↑ GPER1 activation may be favorable in tumor models where selective GPER agonism suppresses proliferation or promotes cell death.

Interpretation Note: GPER1 should be distinguished from the classical nuclear estrogen receptors ESR1/ERα and ESR2/ERβ. Some compounds classified as anti-estrogens at classical estrogen receptors, including tamoxifen and fulvestrant, can act as GPER agonists.
Scientific Papers found: Click to Expand⟱
8308- FS,  lign,    The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1
- in-vivo, BPH, NA
*eff↑, *other↝, *GPER↑, *TumCCA↑, *P53↑, *P21↑, *cycD1/CCND1↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GPER↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 7

Scientific Paper Hit Count for: GPER, G Protein-Coupled Estrogen Receptor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1802  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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