END Cancer Research Results

END, Enterodiol: Click to Expand ⟱
Source:
Type:

Enterodiol

Abbreviation: END, ED

Type: Mammalian lignan / enterolignan / gut-microbiota-derived phytoestrogen metabolite

Source: Produced by intestinal microbiota from dietary plant lignans, including secoisolariciresinol and related lignan precursors derived from foods such as flaxseed, sesame, whole grains, legumes, fruits, and vegetables.

Function: Enterodiol is an intermediate mammalian lignan produced during microbial metabolism of plant lignans and can be further converted to enterolactone. It has weak estrogenic and antiestrogenic activity and may influence estrogen-receptor signaling, oxidative stress, inflammation, and cell proliferation.

Cancer: ↕ Context-dependent but generally protective/anticancer in experimental models. Enterodiol has demonstrated antiproliferative effects in selected cancer cells, including colon cancer models, and may contribute to the cancer-preventive effects associated with lignan-rich diets.

Pathway Relationship: Plant lignans such as SDG/SECO → Enterodiol → Enterolactone.

Interpretation Note: Enterodiol is generated by gut microbiota and should be distinguished from its plant lignan precursors. Exposure can vary substantially depending on gut-microbiome composition and lignan metabolism.
Scientific Papers found: Click to Expand⟱
8312- lign,    Influence of Flaxseed Lignan Supplementation to Older Adults on Biochemical and Functional Outcome Measures of Inflammation
- Trial, Nor, NA
*Dose↝, *END↑, *ENL↑, *BP↓,
8311- lign,    The Power of Lignans: Plant Compounds with Multifaceted Health-Promoting Effects
*cardioP↑, *AntiDiabetic↑, *Obesity↓, *Bacteria↓, *AntiFungal↑, *AntiViral↑, *neuroP↑, *antiOx↑, *lipid-P↓, *memory↑, *CREB↑, *BDNF↑, *PSD95↑, *β-Amyloid↓, *TNF-α↓, *IL6↓, *IL10↓, *GutMicro↑, *Endoglin↑, *END↑, *cognitive↑, *Akt↓, *IκB↓, *NF-kB↓, *HO-1↑, *VEGF↑, *p‑eNOS↑, *GRP78/BiP↓, *PERK↓, *ATF4↓, *CHOP/DDIT3↓, *SREBP1/SREBF1↓, *ROS↓, TumVol↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Functional Outcomes(tgid=23) ⓘ

TumVol↓, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

END↑, 2,   ENL↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

CREB↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   GRP78/BiP↓, 1,   PERK↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   Endoglin↑, 1,   p‑eNOS↑, 1,   VEGF↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↓, 1,   IL6↓, 1,   IκB↓, 1,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,   PSD95↑, 1,  

Protein Aggregation(tgid=19) ⓘ

β-Amyloid↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   cardioP↑, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   Obesity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 37

Scientific Paper Hit Count for: END, Enterodiol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1803  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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