ENL Cancer Research Results

ENL, Enterolactone: Click to Expand ⟱
Source:
Type:

Enterolactone

Abbreviation: ENL, EL

Type: Mammalian lignan / enterolignan / gut-microbiota-derived phytoestrogen metabolite

Source: Produced by intestinal microbiota from dietary lignans, commonly through conversion of enterodiol and related plant-lignan metabolites. Flaxseed is one of the richest dietary sources of enterolignan precursors.

Function: Enterolactone is a major circulating mammalian lignan and biologically active metabolite of dietary plant lignans. It can modulate estrogen-receptor signaling and has antioxidant, anti-inflammatory, antiproliferative, antiangiogenic, and antimetastatic activities in experimental models.

Cancer: ↓ Cancer-promoting activity / ↑ anticancer activity in many experimental contexts. Higher enterolactone exposure has been associated in several studies with reduced risk or improved outcomes in selected cancers, including breast, prostate, colorectal, and other cancers, although epidemiological findings are not completely consistent.

Favorable Direction in Cancer: ↑ Enterolactone exposure/activity is generally favorable in experimental and observational cancer literature, particularly where estrogen signaling, proliferation, angiogenesis, inflammation, or metastasis are involved.

Pathway Relationship: Plant lignans such as SDG/SECO → Enterodiol → Enterolactone.

Interpretation Note: Enterolactone is not present in high concentrations in the original plant food; it is produced by gut microbial metabolism. Therefore, flaxseed lignan content and circulating enterolactone concentration are related but are not equivalent measurements.
Scientific Papers found: Click to Expand⟱
8314- lign,    Reduction in Ki-67 in Benign Breast Tissue of High Risk Women with the Lignan Secoisolariciresinol Diglycoside (SDG)
- Trial, BC, NA
Dose↝, ENL↑, Ki-67↓, BioAv↑,
8312- lign,    Influence of Flaxseed Lignan Supplementation to Older Adults on Biochemical and Functional Outcome Measures of Inflammation
- Trial, Nor, NA
*Dose↝, *END↑, *ENL↑, *BP↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ENL↑, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

END↑, 1,   ENL↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: ENL, Enterolactone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1804  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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