NR3C2/MR Cancer Research Results

NR3C2/MR, Nuclear Receptor Subfamily 3 Group C Member 2 / Mineralocorticoid Receptor: Click to Expand ⟱
Source:
Type:

NR3C2 - Nuclear Receptor Subfamily 3 Group C Member 2 / Mineralocorticoid Receptor

Abbreviation: NR3C2, MR

Alternative Names: Mineralocorticoid Receptor, Aldosterone Receptor

Type: Ligand-activated nuclear receptor / steroid hormone receptor / transcription factor

Function: NR3C2 encodes the mineralocorticoid receptor, which binds aldosterone and, in some tissues, glucocorticoids such as cortisol. Activated NR3C2 regulates transcription involved in sodium and water balance, blood pressure, cardiovascular function, stress responses, metabolism, inflammation, and central nervous system function.

Cancer: ↕ Context-dependent. NR3C2 can function as a tumor suppressor in several cancers, and reduced expression has been associated with aggressive disease and poor prognosis in clear-cell renal cell carcinoma. However, mineralocorticoid receptor signaling can have different effects depending on tumor type, ligand availability, and tissue context.

Favorable Direction in Cancer: Context-dependent. ↑ NR3C2 expression or activity may be favorable in tumors where NR3C2 functions as a tumor suppressor, while excessive mineralocorticoid signaling may be unfavorable in other settings.

Alzheimer's Disease: ↕ Dysregulated mineralocorticoid receptor signaling may contribute to abnormal stress responses, HPA-axis dysfunction, hippocampal impairment, neuroinflammation, and cognitive decline. NR3C2 genetic variants have been associated with differences in memory performance and memory decline.

Favorable Direction in Alzheimer's Disease: Restoration of balanced MR signaling may be favorable. ↑ MR activity can be neuroprotective in some experimental and neuroendocrine contexts, but excessive or imbalanced corticosteroid signaling should not automatically be considered beneficial.
Scientific Papers found: Click to Expand⟱
8324- LIN,    Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression
- vitro+vivo, GC, NA
TumCP↓, TumCMig↓, TumCI↓, NR3C2/MR↑, NR3C2/MR↑, NFKBIZ/IκBζ↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NFKBIZ/IκBζ↓, 1,   NR3C2/MR↑, 2,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NR3C2/MR, Nuclear Receptor Subfamily 3 Group C Member 2 / Mineralocorticoid Receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1805  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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