NFKBIZ/IκBζ Cancer Research Results

NFKBIZ/IκBζ, Nuclear Factor Kappa B Inhibitor Zeta: Click to Expand ⟱
Source:
Type:

NFKBIZ - Nuclear Factor Kappa B Inhibitor Zeta

Abbreviation: NFKBIZ, IκBζ, I-kappa-B-zeta

Type: Atypical nuclear IκB-family protein / NF-κB transcriptional regulator / inflammatory signaling regulator

Function: NFKBIZ encodes IκBζ, an inducible nuclear regulator of NF-κB-dependent transcription. It interacts particularly with NF-κB p50 and p52 homodimers and can either activate or repress selected inflammatory and immune-response genes. NFKBIZ is strongly induced downstream of Toll-like receptor and IL-1 signaling and contributes to regulation of cytokines, antimicrobial genes, and immune-cell differentiation.

Cancer: ↕ Context-dependent. ↑ NFKBIZ is oncogenic in several lymphoid malignancies, particularly activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), where increased IκBζ supports NF-κB-dependent survival and inflammatory gene expression. In solid tumors, NFKBIZ can have either tumor-promoting or tumor-suppressive effects depending on tissue and signaling context.

Favorable Direction in Cancer: Context-dependent. ↓ NFKBIZ may be favorable in tumors such as ABC-DLBCL that depend on IκBζ-driven NF-κB signaling, whereas loss of NFKBIZ may be unfavorable in cancers where it exerts tumor-suppressive effects.

Inflammation: ↑ NFKBIZ generally promotes expression of a subset of NF-κB-dependent inflammatory genes downstream of TLR and IL-1 signaling, although it can also repress selected targets.

Interpretation Note: NFKBIZ/IκBζ should not be treated as equivalent to classical IκBα/NFKBIA. IκBζ is predominantly a nuclear transcriptional regulator and can enhance rather than simply inhibit NF-κB signaling.
Scientific Papers found: Click to Expand⟱
8324- LIN,    Linalool targets NR3C2 to inhibit NF-κB-mediated gastric cancer progression
- vitro+vivo, GC, NA
TumCP↓, TumCMig↓, TumCI↓, NR3C2/MR↑, NR3C2/MR↑, NFKBIZ/IκBζ↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NFKBIZ/IκBζ↓, 1,   NR3C2/MR↑, 2,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NFKBIZ/IκBζ, Nuclear Factor Kappa B Inhibitor Zeta
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1806  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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