OGF Cancer Research Results

OGF, Opioid Growth Factor: Click to Expand ⟱
Source:
Type:

OGF - Opioid Growth Factor

Abbreviation: OGF, [Met5]-enkephalin, Methionine-Enkephalin, MENK

Type: Endogenous opioid peptide / growth-regulatory ligand

Function: OGF is an endogenous pentapeptide that binds the opioid growth factor receptor (OGFr) and tonically suppresses cell proliferation. OGF-OGFr signaling delays progression through the G1/S interface of the cell cycle by increasing cyclin-dependent kinase inhibitory pathways.

Cancer: ↓ Tumor-cell proliferation / ↑ growth inhibition. OGF has demonstrated antiproliferative activity in multiple cancer models by activating OGFr-dependent cell-cycle inhibition. Its effects are generally cytostatic rather than directly cytotoxic and are not primarily mediated by apoptosis.

Favorable Direction in Cancer: ↑ OGF signaling is generally favorable where the OGF-OGFr axis remains functional.

Interpretation Note: OGF is chemically [Met5]-enkephalin but its growth-regulatory effects are mediated primarily through OGFr rather than the classical μ-, δ-, or κ-opioid receptors.

OGFR - Opioid Growth Factor Receptor
Scientific Papers found: Click to Expand⟱
8336- LDN,    Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin
- in-vivo, Ovarian, NA
Dose↝, ChemoSen↑, Weight↑, OGF↑, OGFr↑,
8335- LDN,    The opioid growth factor (OGF) and low dose naltrexone (LDN) suppress human ovarian cancer progression in mice
- vitro+vivo, Ovarian, SKOV3
OGF↑, OGFr↑, Dose↝, TumW↓, TumNum?, TumCP↓, angioG↓, toxicity↓,
8334- LDN,    Low-dose naltrexone targets the opioid growth factor-opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model
- in-vitro, Ovarian, NA
OGFr↑, OGF↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

OGF↑, 3,   OGFr↑, 3,   TumNum?, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 2,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,   TumW↓, 1,   Weight↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: OGF, Opioid Growth Factor
3 low dose naltrexone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1807  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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