XRCC1 Cancer Research Results

XRCC1, X-Ray Repair Cross Complementing 1: Click to Expand ⟱
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XRCC1 - X-Ray Repair Cross Complementing 1

Abbreviation: XRCC1

Type: DNA repair scaffold protein / base excision repair regulator / single-strand break repair protein

Function: XRCC1 is a non-enzymatic scaffold protein that coordinates repair of DNA single-strand breaks and lesions processed through the base excision repair pathway. It interacts with repair proteins including PARP1/PARP2, DNA polymerase β, PNKP, APE1, and DNA ligase III to assemble and stabilize DNA repair complexes.

Cancer: ↕ Context-dependent. Normal XRCC1-mediated DNA repair protects genomic integrity and can reduce accumulation of carcinogenic mutations. However, established cancer cells can exploit XRCC1-dependent repair to survive DNA-damaging chemotherapy and radiation, contributing to treatment resistance.

Favorable Direction in Cancer: Context-dependent. ↑ XRCC1 function may be protective during cancer prevention by maintaining genomic stability, whereas ↓ XRCC1 activity can increase sensitivity of established tumors to DNA-damaging treatment.

Alzheimer's Disease: ↓ / impaired XRCC1-mediated DNA repair may be unfavorable. Defective base excision and single-strand break repair are reported in Alzheimer's disease, and reduced XRCC1 expression has been observed in Aβ-exposed neuronal cells. XRCC1 genetic variants have also been investigated in relation to DNA damage and Alzheimer's disease susceptibility.

Favorable Direction in Alzheimer's Disease: ↑ Restoration of normal XRCC1-dependent DNA repair is generally favorable where BER/SSBR is impaired.

Interpretation Note: XRCC1 has no known catalytic repair activity of its own; its primary function is to organize and stabilize other DNA repair proteins at sites of damage.
Scientific Papers found: Click to Expand⟱
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, eff↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8342- Lut,  Cisplatin,    Lutein Influences Cisplatin Sensitivity Through Differential Regulation of DNA Damage Response Genes in Breast Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
tumCV↓, DNAdam↑, selectivity↑, ROS↑, Casp3↑, BRCA1↓, Ku70/XRCC6↓, XRCC1↓, ChemoSen↑, NA↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

compV↓, 1,   ERCC3↑, 1,   Ku70/XRCC6↓, 1,   miR-107↑, 1,   miR-224↓, 1,   miR-422a↑, 1,   MMP16↓, 1,   NA↓, 1,   PTN↓, 1,   XRCC1↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   HK1↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   compIII↓, 1,   ETC↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Ferroptosis↑, 1,   p‑MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↓, 1,   p‑CHK1↑, 1,   DNAdam↑, 1,   DNArepair↓, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   p‑ERK↓, 1,   FOXO1↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↑, 1,   mTOR↓, 1,   NOTCH↓, 1,   PI3K↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   Ki-67↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-340↓, 1,   miR-384↑, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP?, 1,   TumCP↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 2,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BRCA1↓, 1,   Ki-67↓, 1,  
Total Targets: 72

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: XRCC1, X-Ray Repair Cross Complementing 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1810  State#:%  Dir#:%
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