miR-590-3p Cancer Research Results

miR-590-3p, MicroRNA-590-3p: Click to Expand ⟱
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miR-590-3p - MicroRNA-590-3p

Abbreviation: miR-590-3p

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-590-3p is a mature microRNA derived from MIR590 that regulates gene expression by binding target mRNAs and promoting translational repression or mRNA degradation. Its targets vary substantially by tissue and disease context.

Cancer: ↕ Context-dependent. miR-590-3p functions as a tumor suppressor in several cancers, including breast cancer and glioblastoma, where restoration can reduce proliferation, migration, invasion, epithelial-to-mesenchymal transition, and metastasis or increase apoptosis. Reported targets include SIRT1, ZEB1, ZEB2, SNAI2/Slug, ATF3, RUNX2, and TEAD1. In contrast, miR-590-3p can act as an oncogenic miRNA in colorectal cancer, where increased expression has been associated with proliferation, invasion, metastasis, Hippo/YAP activation, and Wnt/β-catenin signaling.

Favorable Direction in Cancer: Context-dependent. ↑ miR-590-3p is favorable where it acts as a tumor-suppressive miRNA, whereas ↓ miR-590-3p may be favorable in colorectal cancer and other settings where it functions as an oncomiR.

Alzheimer's Disease: ↕ / preliminary evidence. Reduced miR-590-3p expression has been observed in peripheral blood mononuclear cells from Alzheimer's disease patients and was inversely correlated with hnRNP-A1 expression, but the disease direction is not yet sufficiently established for a firm universal arrow.

Interpretation Note: miR-590-3p should not be assigned a universal cancer direction. Tumor type and experimentally validated downstream target should determine whether increased or decreased miR-590-3p is favorable.
Scientific Papers found: Click to Expand⟱
8343- Lut,    Association of Lutein with Cancer: A Systematic Review of the Lutein Effects on Cellular Processes Involved in Cancer Progression
- Review, Var, NA
*antiOx↑, *Inflam↓, Risk↓, AntiCan∅, Apoptosis↑, ROS↓, NRF2↓, Akt↓, ERK↓, NF-kB↓, Bcl-2↓, BAX↑, Casp3↑, DNAdam↑, ROS↓, P53↑, PCNA↓, cycD1/CCND1↓, TumCP↓, Hif1a↓, NOTCH↓, miR-590-3p↑, TumCMig↓, TumCI↓, TumMeta↓, TumCA↓, *BioAv↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-590-3p↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   NOTCH↓, 1,  

Migration(tgid=13) ⓘ

TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan∅, 1,   Risk↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: miR-590-3p, MicroRNA-590-3p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1811  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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