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| Abbreviation: TNFRSF21, DR6, CD358 Alternative Names: BM-018 Type: Death receptor / TNF receptor superfamily member / apoptosis and inflammatory signaling receptor Function: TNFRSF21/DR6 contains an intracellular death domain and can activate apoptotic signaling as well as NF-κB and JNK/MAPK8 pathways. It participates in immune regulation, inflammation, neuronal degeneration, axonal pruning, and vascular signaling. Cancer: ↕ Context-dependent. DR6 can promote apoptosis in some cancer cells, but DR6 signaling can also contribute to tumor-associated inflammation, endothelial cell death, tumor-cell extravasation, and metastatic progression depending on cellular context. Favorable Direction in Cancer: Context-dependent. ↑ DR6 signaling may be favorable when it induces tumor-cell apoptosis, whereas ↓ DR6 may be favorable when endothelial or inflammatory DR6 signaling promotes metastasis. Neurologic Relevance: ↑ DR6 signaling can promote axonal degeneration and neuronal loss in injury-related and neurodegenerative contexts; inhibition of DR6 has shown neuroprotective effects experimentally. |
| 8347- | Lut, | Carotenoid Lutein Selectively Inhibits Breast Cancer Cell Growth and Potentiates the Effect of Chemotherapeutic Agents through ROS-Mediated Mechanisms |
| - | in-vitro, | BC, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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