SNAP25 Cancer Research Results

SNAP25, Synaptosome Associated Protein 25: Click to Expand ⟱
Source:
Type:

SNAP25 - Synaptosome Associated Protein 25

Abbreviation: SNAP25, SNAP-25

Type: SNARE complex protein / presynaptic protein / synaptic vesicle fusion regulator

Function: SNAP-25 is a presynaptic membrane-associated protein and core component of the neuronal SNARE complex. Together with syntaxin and VAMP/synaptobrevin, SNAP-25 mediates docking and fusion of synaptic vesicles with the presynaptic membrane and is essential for calcium-dependent neurotransmitter release.

Alzheimer's Disease: ↓ SNAP-25 expression or synaptic SNAP-25 function is associated with synaptic degeneration and impaired neurotransmission in Alzheimer's disease. Loss of SNAP-25-containing presynaptic terminals reflects deterioration of synaptic integrity.

Favorable Direction in Alzheimer's Disease: ↑ Preservation or restoration of normal SNAP-25 expression and synaptic function is generally favorable.

Biomarker Note: ↑ SNAP-25 concentration in cerebrospinal fluid can indicate increased synaptic or neuronal injury and should not be interpreted the same way as ↑ SNAP-25 expression within functional brain synapses.

Cancer: ↕ Context-dependent / insufficient evidence for a useful general cancer direction.

Interpretation Note: Distinguish tissue or neuronal SNAP-25 expression from extracellular or CSF SNAP-25 used as a biomarker of synaptic damage.
Scientific Papers found: Click to Expand⟱
8382- LT,    Luteolin as a dietary flavonoid for brain health: modulating neuroinflammation and cognitive decline in neurodegenerative disorders
- Review, AD, NA - Review, Park, NA
*neuroP↑, *Inflam↓, *antiOx↑, *NF-kB↓, *NRF2↑, *BDNF↑, *cognitive↑, *motorD↑, *BBB↑, *BioAv↓, *NO↓, *ROS↓, *NRF2↑, *ARE↑, *MMP↑, *BDNF↑, *Learn↑, *memory↑, *cognitive↑, *p‑JNK↓, *GFAP↓, *AIF1/Iba-1↓, *TNF-α↓, *IL1β↓, *BAX↓, *COX2/PTGS2↓, *BACE/β-secretase↓, *Aβ42↓, *PSD95↑, *SNAP25↑, *lipid-P↓, *GSTs↓, *GSH↑, *SOD↓, *Catalase↓, *AChE↓, *Casp3↓, *Casp9↓,
8379- LT,    Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
*neuroP↑, *Inflam↓, *ROS↓, *Apoptosis↓, *BioAv↓, *BBB∅, Ferroptosis↑, ROS↑, Iron↑, lipid-P↑, MDA↑, GSH↓, GPx4↓, *Aβ↓, *memory↑, *neuroG↑, *NRF2↑, *NLRP3↓, *ROS↓, JAK2↓, STAT3↓, PD-L1↓, Perforin↝, GranB/GZMB↝, hepatoP↑, *Learn↑, *TNF-α↓, *IL1β↓, *IL6↓, *NO↓, *COX2/PTGS2↓, *iNOS↓, *ER Stress↓, *GRP78/BiP↓, *IRE1↓, *cognitive↑, *BAX↓, *Bcl-2↓, *Casp3↓, *PSD95↑, *SNAP25↑, *JNK↓, *eff↑, *mtDam↓, *MMP↑, *Stroke↓, *TJ↑, *MMP9↓, *BBB∅, *NeuroI↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   Iron↑, 1,   lipid-P↑, 1,   MDA↑, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,   GranB/GZMB↝, 1,   Perforin↝, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK2↓, 1,   PD-L1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AIF1/Iba-1↓, 1,   Aβ42↓, 1,   GFAP↓, 1,   Learn↑, 2,   NeuroI↓, 1,   SNAP25↑, 2,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↓, 1,   GSH↑, 1,   GSTs↓, 1,   lipid-P↓, 1,   NRF2↑, 3,   ROS↓, 3,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 2,   mtDam↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,   BAX↓, 2,   Bcl-2↓, 1,   Casp3↓, 2,   Casp9↓, 1,   iNOS↓, 1,   JNK↓, 1,   p‑JNK↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↓, 1,   GRP78/BiP↓, 1,   IRE1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

neuroG↑, 1,  

Migration(tgid=13) ⓘ

MMP9↓, 1,   TJ↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   BBB∅, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   IL1β↓, 2,   IL6↓, 1,   Inflam↓, 2,   NF-kB↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   BDNF↑, 2,   PSD95↑, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   BACE/β-secretase↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 3,   memory↑, 2,   motorD↑, 1,   neuroP↑, 2,  
Total Targets: 54

Scientific Paper Hit Count for: SNAP25, Synaptosome Associated Protein 25
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1816  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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