MMP16 Cancer Research Results

MMP16, Matrix Metallopeptidase 16: Click to Expand ⟱
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Type:

MMP16 - Matrix Metallopeptidase 16

Abbreviation: MMP16, MT3-MMP

Alternative Names: Membrane-Type 3 Matrix Metalloproteinase, MT-MMP3

Type: Membrane-type matrix metalloproteinase / zinc-dependent endopeptidase / extracellular-matrix remodeling enzyme

Function: MMP16 is a membrane-associated matrix metalloproteinase that degrades extracellular-matrix components and can activate pro-MMP2. It regulates extracellular-matrix remodeling, cell migration, tissue invasion, and interactions between cells and the tumor microenvironment.

Cancer: ↑ MMP16 expression or activity is associated in several cancers with extracellular-matrix degradation, migration, invasion, metastasis, and tumor progression. MMP16 can promote invasive behavior directly through matrix proteolysis and indirectly through activation of other metalloproteinases such as MMP2.

Favorable Direction in Cancer: ↓ MMP16 expression or proteolytic activity is generally favorable where MMP16 promotes tumor invasion, extracellular-matrix remodeling, and metastasis.

Pathway Relationship: MMP16 ↑ → pro-MMP2 activation ↑ → extracellular-matrix degradation ↑ → invasion/metastasis ↑.
Scientific Papers found: Click to Expand⟱
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, eff↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,
8401- LT,    Multi-Faceted Role of Luteolin in Cancer Metastasis: EMT, Angiogenesis, ECM Degradation and Apoptosis
- Review, Var, NA
EMT↓, N-cadherin↓, Vim↓, VEGF↓, VEGFR1↓, MMPs↓, Telomerase↓, NF-kB↓, cMyc↓, Bax:Bcl2↑, Casp3↑, PI3K↓, Akt↓, FOXO3↑, P21↑, p27/CDKN1B↑, cl‑PARP↑, Cyt‑c↑, NOTCH↓, HES1↓, ROS↑, SOD↓, miR-34b-5p↑, Hif1a↓, P21↓, survivin↓, Mcl-1?, Bcl-xL↓, MDM2↓, MMP2↓, MMP9↓, MMP3↓, MMP16↓, miR-384↑, NRF2↓, HO-1↓, angioG↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

compV↓, 1,   ERCC3↑, 1,   HES1↓, 1,   miR-107↑, 2,   miR-224↓, 2,   miR-422a↑, 2,   MMP16↓, 3,   PTN↓, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   HK1↓, 1,   HO-1↓, 1,   NRF2↓, 1,   ROS↑, 2,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   compIII↓, 1,   ETC↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Apoptosis↑, 2,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   MAPK↓, 1,   p‑MAPK↓, 1,   Mcl-1?, 1,   MDM2↓, 1,   p27/CDKN1B↑, 1,   survivin↓, 1,   Telomerase↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑CHK1↑, 1,   DNArepair↓, 1,   P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   P21↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   p‑ERK↓, 1,   FOXO1↓, 1,   FOXO3↑, 1,   IGF-1R↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↑, 2,   mTOR↓, 2,   NOTCH↓, 3,   PI3K↓, 3,   STAT3↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-340↓, 2,   miR-384↑, 2,   MMP2↓, 3,   MMP3↓, 3,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumCP?, 1,   TumCP↓, 2,   TumMeta↓, 1,   VEGFR1↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 1,   miR-34b-5p↑, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   IL6↓, 1,   NF-kB↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol∅, 1,   TumW∅, 1,  
Total Targets: 103

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: MMP16, Matrix Metallopeptidase 16
3 Luteolin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1820  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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