miR-422a Cancer Research Results

miR-422a, MicroRNA-422a: Click to Expand ⟱
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miR-422a - MicroRNA-422a

Abbreviation: miR-422a

Type: MicroRNA / post-transcriptional gene-expression regulator

Function: miR-422a is a small non-coding RNA that regulates gene expression by binding target mRNAs and promoting transcript degradation or translational repression. It has been implicated in control of cell proliferation, migration, invasion, and oncogenic signaling.

Cancer: ↓ miR-422a is reduced in several cancer contexts and commonly functions as a tumor-suppressive microRNA. In glioblastoma, reduced miR-422a is associated with increased malignancy, while restoration of miR-422a suppresses proliferation, migration, and invasion through direct targeting of PIK3CA and inhibition of PI3K/AKT signaling.

Favorable Direction in Cancer: ↑ Restoration of miR-422a is generally favorable where it acts as a tumor suppressor.

Known Target Relationship: miR-422a ↑ → PIK3CA ↓ → PI3K/AKT signaling ↓ → proliferation/invasion/migration ↓.
Scientific Papers found: Click to Expand⟱
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, eff↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8397- LT,    Effects and Mechanisms of Luteolin, a Plant-Based Flavonoid, in the Prevention of Cancers via Modulation of Inflammation and Cell Signaling Molecules
- Review, Var, NA
tumCV↓, TumCP↓, angioG↓, TumCI↓, TumMeta↓, mTOR↓, PI3K↓, Akt↓, STAT3↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Apoptosis↑, hTERT/TERT↓, AP-1↓, NF-kB↓, MAPK↓, HSP90↓, AR↓, IGF-1R↓, Akt↓, NOTCH↓, IL6↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, TumVol∅, TumW∅, miR-34a↑, miR-107↑, miR-139-5p↑, miR-422a↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, *toxicity↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

compV↓, 1,   ERCC3↑, 1,   miR-107↑, 2,   miR-224↓, 2,   miR-422a↑, 2,   MMP16↓, 2,   PTN↓, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   GSH↓, 1,   HK1↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   compIII↓, 1,   ETC↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   Ferroptosis↑, 1,   hTERT/TERT↓, 1,   MAPK↓, 1,   p‑MAPK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑CHK1↑, 1,   DNArepair↓, 1,   P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   p‑ERK↓, 1,   FOXO1↓, 1,   IGF-1R↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-34a↑, 2,   mTOR↓, 2,   NOTCH↓, 2,   PI3K↓, 2,   STAT3↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   E-cadherin↑, 1,   Ki-67↓, 1,   miR-139-5p↑, 2,   miR-155↓, 2,   miR-340↓, 2,   miR-384↑, 1,   MMP2↓, 2,   MMP3↓, 2,   MMP9↓, 2,   N-cadherin↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumCP?, 1,   TumCP↓, 2,   TumMeta↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

HMGB1↓, 1,   IL6↓, 1,   NF-kB↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↝, 1,   ChemoSen↑, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 1,   Ki-67↓, 1,  

Functional Outcomes(tgid=23) ⓘ

TumVol∅, 1,   TumW∅, 1,  
Total Targets: 80

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: miR-422a, MicroRNA-422a
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1821  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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