CXCL16 Cancer Research Results

CXCL16, SR-PSOX, C-X-C Motif Chemokine Ligand 16: Click to Expand ⟱
Source:
Type:

CXCL16 - C-X-C Motif Chemokine Ligand 16

Abbreviation: CXCL16

Alternative Names: SR-PSOX, Scavenger Receptor for Phosphatidylserine and Oxidized LDL

Type: Chemokine / membrane-associated cytokine / soluble chemotactic factor / scavenger receptor-like protein

Function: CXCL16 exists as both a transmembrane protein and a soluble chemokine. It binds the receptor CXCR6 and regulates leukocyte recruitment, cell adhesion, migration, inflammatory signaling, and tissue immune responses. Membrane-associated CXCL16 can also function as a scavenger receptor for oxidized lipids.

Cancer: ↑ CXCL16 expression or CXCL16-CXCR6 signaling is increased in several cancers and can promote tumor-cell proliferation, migration, invasion, angiogenesis, metastasis, and tumor-microenvironment signaling. However, CXCL16 can also recruit CXCR6-positive antitumor immune cells in some settings, making its net effect context-dependent.

Favorable Direction in Cancer: ↓ CXCL16/CXCR6 signaling is generally favorable where the pathway directly promotes tumor growth, invasion, or metastasis. In immune-dominant contexts, increased CXCL16-mediated recruitment of cytotoxic lymphocytes may instead support antitumor immunity.

Pathway Relationship: CXCL16 ↑ → CXCR6 activation ↑ → migration/invasion and downstream survival signaling ↑ in susceptible tumor cells.
Scientific Papers found: Click to Expand⟱
8393- LT,    Progress, pharmacokinetics and future perspectives of luteolin modulating signaling pathways to exert anticancer effects: A review
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, EMT↓, Imm↝, ChemoSen↑, *Inflam↓, *COX2/PTGS2↓, *NF-kB↓, MMP2↓, MMP9↓, p‑Akt↓, p‑PI3K↓, IGF-2↓, IGF-1R↓, CXCL16↓, NOTCH1↓, HES1↓, VEGF↓, ROS↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CXCL16↓, 1,   HES1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,   IGF-1R↓, 1,   IGF-2↓, 1,   NOTCH1↓, 1,   p‑PI3K↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TumCP↓, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: CXCL16, SR-PSOX, C-X-C Motif Chemokine Ligand 16
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1824  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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