SGK1 Cancer Research Results

SGK1, Serum/Glucocorticoid Regulated Kinase 1: Click to Expand ⟱
Source:
Type:

SGK1 - Serum/Glucocorticoid Regulated Kinase 1

Abbreviation: SGK1

Type: Serine/threonine kinase / AGC-family kinase / PI3K-pathway effector

Function: SGK1 is a serum- and glucocorticoid-responsive serine/threonine kinase activated downstream of PI3K through PDK1 and mTORC2. It regulates cell survival, proliferation, apoptosis, ion channels, nutrient transport, metabolism, autophagy, inflammatory signaling, and stress responses.

Cancer: ↑ SGK1 is overexpressed or hyperactivated in several cancers and can promote tumor-cell survival, proliferation, epithelial-mesenchymal transition, invasion, metastasis, cancer stem-cell activity, metabolic adaptation, and resistance to anticancer therapy.

Favorable Direction in Cancer: ↓ SGK1 expression or kinase activity is generally favorable where SGK1 supports tumor survival, invasion, or treatment resistance.

Alzheimer's Disease: ↕ Context-dependent. SGK1 participates in neuronal survival, stress responses, Aβ metabolism, tau regulation, and neuroinflammation. Excessive SGK1 activity may promote microglial and astrocytic inflammatory signaling, while physiological SGK1 activity can also support neuronal survival and memory-related processes.

Favorable Direction in Alzheimer's Disease: Context-dependent. Excessive/pathological SGK1 signaling may be unfavorable, but complete suppression is not necessarily beneficial because SGK1 also has normal neuronal and homeostatic functions.
Scientific Papers found: Click to Expand⟱
8400- LT,    Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling
- in-vitro, BC, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, SGK1↓, AKT3↓, BNIP3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AKT3↓, 1,   SGK1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↑, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SGK1, Serum/Glucocorticoid Regulated Kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1825  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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