AKT3 Cancer Research Results

AKT3, AKT Serine/Threonine Kinase 3: Click to Expand ⟱
Source:
Type:

AKT3 - AKT Serine/Threonine Kinase 3

Abbreviation: AKT3, PKBγ

Alternative Names: Protein Kinase B Gamma, RAC-gamma Serine/Threonine-Protein Kinase

Type: Serine/threonine kinase / PI3K-AKT signaling protein / AGC-family kinase

Function: AKT3 is one of the three AKT kinase isoforms and is activated downstream of PI3K signaling. It regulates cell survival, proliferation, growth, metabolism, migration, differentiation, and responses to cellular stress. AKT3 is particularly important in brain development and has isoform-specific functions distinct from AKT1 and AKT2.

Cancer: ↑ AKT3 is overexpressed or hyperactivated in several cancers and can promote tumor-cell proliferation, survival, migration, invasion, metastasis, and treatment resistance. Its importance varies substantially by tumor type and genetic context.

Favorable Direction in Cancer: ↓ AKT3 expression or kinase activity is generally favorable in tumors that depend on AKT3-driven PI3K/AKT signaling.
Scientific Papers found: Click to Expand⟱
8400- LT,    Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling
- in-vitro, BC, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, SGK1↓, AKT3↓, BNIP3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AKT3↓, 1,   SGK1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↑, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AKT3, AKT Serine/Threonine Kinase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1826  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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